https://scholars.lib.ntu.edu.tw/handle/123456789/503106
Title: | Hypothyroidism and the risk of developing open-angle glaucoma: A five-year population-based follow-up study | Authors: | Lin H.-C. Kang J.-H. YI-DER JIANG Ho J.-D. |
Issue Date: | 2010 | Journal Volume: | 117 | Journal Issue: | 10 | Start page/Pages: | 1960-1966 | Source: | Ophthalmology | Abstract: | Objective: To investigate the risk of open-angle glaucoma (OAG) after a diagnosis of hypothyroidism. Design: A retrospective, population-based follow-up study using an administrative database. Participants: The study group comprised 257 hypothyroidism patients. The comparison group included 2056 subjects. Methods: Data were retrospectively collected from the Taiwan Longitudinal Health Insurance Database. The study cohort comprised patients aged <60 who received a first diagnosis of hypothyroidism (International Classification of Diseases, Ninth Revision, Clinical Modification code 244.9) from 1997 to 2001 (n = 257). The comparison cohort consisted of randomly selected patients without hypothyroidism who were aged <60 and had no diagnosis of glaucoma before 2001 (8 for every OAG patient; n = 2056). Each sampled patient was tracked for 5 years from their index visit. Cox proportional hazard regressions were used to compute the 5-year OAG-free survival rate, after adjusting for possible confounding factors. Main Outcome Measures: The risk of developing OAG during the 5-year follow-up period. Results: Open-angle glaucoma developed in 7.4% of patients with hypothyroidism and 3.8% of patients in the comparison cohort during the follow-up period. Hypothyroid patients had a significantly lower 5-year OAG-free survival rate than patients in the comparison cohort. After adjusting for patients' age, gender, monthly income, urbanization level, and comorbid medical disorders, hypothyroidism patients were found to have a 1.78-fold (95% confidence interval [CI], 1.043.06) greater risk of developing OAG than the comparison cohort. This association remained significant in untreated hypothyroidism patients (adjusted hazard ratio [HR], 2.37; 95% CI, 1.105.09) and became statistically nonsignificant in patients treated with levothyroxine (adjusted HR, 1.73; 95% CI, 0.893.38). Conclusions: Hypothyroid patients had a significantly increased risk of OAG development during the 5-year follow-up period. Levothyroxine seemed to be protective. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. ? 2010 American Academy of Ophthalmology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77957570078&doi=10.1016%2fj.ophtha.2010.02.005&partnerID=40&md5=9512f486aac3d1629d4bbd5da153bbf7 https://scholars.lib.ntu.edu.tw/handle/123456789/503106 |
ISSN: | 0161-6420 | DOI: | 10.1016/j.ophtha.2010.02.005 | SDG/Keyword: | levothyroxine; thyroxine; aged; article; controlled study; female; follow up; human; hypothyroidism; major clinical study; male; open angle glaucoma; population research; priority journal; retrospective study; risk assessment; survival rate; Taiwan; complication; disease free survival; Glaucoma, Open-Angle; hypothyroidism; middle aged; proportional hazards model; risk factor; Aged; Disease-Free Survival; Female; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Hypothyroidism; Male; Middle Aged; Proportional Hazards Models; Retrospective Studies; Risk Factors; Thyroxine; Aged; Disease-Free Survival; Female; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Hypothyroidism; Male; Middle Aged; Proportional Hazards Models; Retrospective Studies; Risk Factors; Thyroxine |
Appears in Collections: | 醫學系 |
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