https://scholars.lib.ntu.edu.tw/handle/123456789/503567
DC Field | Value | Language |
---|---|---|
dc.contributor.author | SUI-YUAN CHANG | en_US |
dc.contributor.author | Chen M.-Y. | en_US |
dc.contributor.author | Lee C.-N. | en_US |
dc.contributor.author | HSIN-YUN SUN | en_US |
dc.contributor.author | Ko W. | en_US |
dc.contributor.author | Chang S.-F. | en_US |
dc.contributor.author | Chang K.-L. | en_US |
dc.contributor.author | SZU-MIN HSIEH | en_US |
dc.contributor.author | WANG-HUEI SHENG | en_US |
dc.contributor.author | Liu W.-C. | en_US |
dc.contributor.author | Wu C.-H. | en_US |
dc.contributor.author | CHUAN-LIANG KAO | en_US |
dc.contributor.author | CHIEN-CHING HUNG | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.creator | Sui-Yuan Chang;Chen M.-Y.;Lee C.-N.;Sun H.-Y.;Ko W.;Chang S.-F.;Chang K.-L.;Hsieh S.-M.;Sheng W.-H.;Liu W.-C.;Wu C.-H.;Kao C.-L.;Hung C.-C.;Chang S.-C. | - |
dc.date.accessioned | 2020-06-18T08:26:17Z | - |
dc.date.available | 2020-06-18T08:26:17Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0305-7453 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/503567 | - |
dc.description.abstract | Objectives: To determine the prevalence and trends of antiretroviral drug resistance among HIV-1-infected Taiwanese patients who have been provided with free-of-charge antiretroviral therapy (ART) since 1990. Methods: Blood samples collected from 786 HIV-1-infected patients from 1999 to 2006 were subjected to genotypic resistance assay. Antiretroviral resistance mutations were identified in accordance with the antiretroviral resistance mutation list of the International AIDS Society-USA Consensus Guidelines. Trends of resistance were studied in patients enrolled in two periods: before (period 1, January 1999 to December 2003) and after (period 2, January 2004 to December 2006) the CRF07_BC outbreak among injection drug users (IDUs). Results: The frequency of HIV-1 isolates harbouring one or more primary mutations associated with antiretroviral resistance to reverse transcriptase inhibitors or protease inhibitors increased significantly from 6.6% in period 1 to 12.7% in period 2 (P = 0.003). A significant increase in prevalence of antiretroviral drug resistance was observed among men who have sex with men and patients infected with HIV subtype B. In multivariate analysis, hepatitis C virus (HCV) exposure, which exhibited collinearity with injection drug use and infection with CRF07_BC, represented a lower risk for infection with resistant viruses. Conclusions: Our findings suggest that the prevalence of antiretroviralresistance has increased in Taiwan over the past 8 years after the introduction of combination ART. IDUs who were HCV-seropositive and infected with CRF07_BC were at lower risk for infection with antiretroviral-resistant viruses. ? The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. | - |
dc.relation.ispartof | Journal of Antimicrobial Chemotherapy | - |
dc.subject.other | atazanavir; nelfinavir; proteinase inhibitor; RNA directed DNA polymerase inhibitor; adult; antibiotic resistance; article; controlled study; female; hepatitis C; high risk behavior; human; Human immunodeficiency virus 1 infection; Human immunodeficiency virus infected patient; male; male homosexual; medical society; multidrug resistance; mutational analysis; nonhuman; prevalence; superinfection; Taiwan; trend study; virus mutation; virus resistance; Adult; Anti-Retroviral Agents; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Male; Taiwan | - |
dc.subject.other | [SDGs]SDG3 | - |
dc.title | Trends of antiretroviral drug resistance in treatment-naive patients with human immunodeficiency virus type 1 infection in Taiwan | en_US |
dc.type | journal article | - |
dc.identifier.doi | 10.1093/jac/dkn002 | - |
dc.identifier.pmid | 18227088 | - |
dc.identifier.scopus | 2-s2.0-40049092925 | - |
dc.relation.pages | 689-693 | - |
dc.relation.journalvolume | 61 | - |
dc.relation.journalissue | 3 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | School of Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Education-NTUH | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Tropical Medicine and Parasitology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.orcid | 0000-0002-6009-6724 | - |
crisitem.author.orcid | 0000-0003-0074-7721 | - |
crisitem.author.orcid | 0000-0002-1879-4086 | - |
crisitem.author.orcid | 0000-0002-5605-7853 | - |
crisitem.author.orcid | 0000-0002-1020-2605 | - |
crisitem.author.orcid | 0000-0001-7345-0836 | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
Appears in Collections: | 醫學檢驗暨生物技術學系 |
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