https://scholars.lib.ntu.edu.tw/handle/123456789/503578
DC Field | Value | Language |
---|---|---|
dc.contributor.author | SUI-YUAN CHANG | en_US |
dc.contributor.author | WANG-HUEI SHENG | en_US |
dc.contributor.author | Lee C.-N. | en_US |
dc.contributor.author | HSIN-YUN SUN | en_US |
dc.contributor.author | CHUAN-LIANG KAO | en_US |
dc.contributor.author | Chang S.-F. | en_US |
dc.contributor.author | Liu W.-C. | en_US |
dc.contributor.author | Yang J.R.-Y. | en_US |
dc.contributor.author | Wong W.-W. | en_US |
dc.contributor.author | CHIEN-CHING HUNG | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.creator | Chang S.-C.;Hung C.-C.;Wong W.-W.;Yang J.R.-Y.;Liu W.-C.;Chang S.-F.;Kao C.-L.;Sun H.-Y.;Lee C.-N.;Sheng W.-H.;SUI-YUAN CHANG | - |
dc.date.accessioned | 2020-06-18T08:26:20Z | - |
dc.date.available | 2020-06-18T08:26:20Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0889-2229 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/503578 | - |
dc.description.abstract | In Taiwan, sexual transmission is responsible for most HIV-1 infections with two dominant subtypes, subtype B and CRF01_AE, distributing among homosexual and heterosexual groups, respectively. Recently, intravenous drug use has become an emerging route of HIV-1 transmission and contributed to a significant increase of HIV-1 infection. To characterize the HIV isolates responsible for the outbreak among intravenous drug users (IDUs), phylogenetic analysis was performed to analyze the protease/RT sequences amplified from HIV-1-infected IDUs at National Taiwan University Hospital and Taipei City STD Control Center. CRF07_BC, which is circulating in northern China, was demonstrated to account for the majority of HIV-1 infection in IDUs in the past 2 years. Although these Taiwanese CRF07_BC sequences shared the same breakpoint positions as those described in the CRF07_BC reference sequences, they formed a unique cluster in the phylogenetic tree, suggesting they originated from a founder virus. This finding was further supported by the relative low genetic diversity and unique sequence features. Our results demonstrated the emergence of CRF07_BC and its association with the HIV-1 outbreak among IDUs between 2004 and 2005 in Taiwan. This finding not only helps us to have a better understanding of the HIV evolution in Asia, but also has important implications for vaccine design in the future. ? Mary Ann Liebert, Inc. | - |
dc.relation.ispartof | AIDS Research and Human Retroviruses | - |
dc.subject.other | adult; article; epidemic; female; founder effect; gene sequence; genetic variability; human; Human immunodeficiency virus 1; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; Human immunodeficiency virus prevalence; intravenous drug abuse; major clinical study; male; molecular epidemiology; nucleotide sequence; phylogenetic tree; phylogeny; polymerase chain reaction; priority journal; sequence analysis; Taiwan; unindexed sequence; virus isolation; virus transmission; Disease Outbreaks; Epidemiology, Molecular; HIV Infections; HIV-1; Humans; Molecular Sequence Data; Phylogeny; Substance Abuse, Intravenous; Taiwan; Time Factors | - |
dc.subject.other | [SDGs]SDG3 | - |
dc.title | Molecular epidemiology of HIV type 1 subtypes in Taiwan: Outbreak of HIV type 1 CRF07_BC infection in intravenous drug users | en_US |
dc.type | journal article | - |
dc.identifier.doi | 10.1089/aid.2006.22.1055 | - |
dc.identifier.pmid | 17147490 | - |
dc.identifier.scopus | 2-s2.0-33845430500 | - |
dc.relation.pages | 1055-1066 | - |
dc.relation.journalvolume | 22 | - |
dc.relation.journalissue | 11 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | School of Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Education-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Tropical Medicine and Parasitology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.orcid | 0000-0002-6009-6724 | - |
crisitem.author.orcid | 0000-0002-5605-7853 | - |
crisitem.author.orcid | 0000-0003-0074-7721 | - |
crisitem.author.orcid | 0000-0002-1020-2605 | - |
crisitem.author.orcid | 0000-0001-7345-0836 | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
Appears in Collections: | 醫學檢驗暨生物技術學系 |
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