https://scholars.lib.ntu.edu.tw/handle/123456789/504010
標題: | Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice | 作者: | Liao H.-J. Chyuan I.-T. Wu C.-S. SHU-WHA LIN Chen K.-H. Tsai H.-F. PING-NING HSU |
公開日期: | 2015 | 卷: | 54 | 期: | 7 | 起(迄)頁: | 1317_1326 | 來源出版物: | Rheumatology (United Kingdom) | 摘要: | Objective. Proline-serine-threonine-phosphatase-interacting protein 2 (PSTPIP2) is involved in macrophage activation, neutrophil motility and osteoclast differentiation. However, the role of PSTPIP2 in inflammation and autoinflammatory diseases is still not clear. In this study, we generated PSTPIP2 knockout (Pstpip2-/-) mice to investigate its phenotype and role in autoinflammatory diseases. Methods. We constructed a Pstpip2-targeting vector and generated Pstpip2-/- mice. The phenotype and immunopathology of Pstpip2-/- mice were analysed. Results. All Pstpip2-/- mice developed paw swelling, synovitis, hyperostosis and osteitis, resembling SAPHO syndrome, an inflammatory disorder of the bone, skin and joints. Multifocal osteomyelitis was found in inflamed paws, with increased macrophage and marked neutrophil infiltrations in the bone, joint and skin. Profound osteolytic lesions with markedly decreased bone volume density developed in paws and limbs. Neutrophil-attracting chemokines and IL-1β were markedly elevated in inflamed tissues. Conclusion. Our study suggests that PSTPIP2 could play a role in innate immunity and development of autoinflammatory bone disorders, and may be associated with the pathogenesis of human SAPHO syndrome. ? The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/504010 | ISSN: | 1462-0324 | DOI: | 10.1093/rheumatology/keu481 | SDG/關鍵字: | chemokine; interleukin 1; interleukin 1beta; proline serine threonine phosphatase interacting protein 2; protein; unclassified drug; animal experiment; animal model; animal tissue; arthritis; Article; autoinflammatory disease; bone atrophy; bone density; bone disease; bone mass; controlled study; cytokine production; dermatitis; gene targeting; gene vector; hyperostosis; immunopathology; innate immunity; knockout mouse; lymphadenopathy; macrophage; mouse; neutrophil chemotaxis; nonhuman; osteitis; osteomyelitis; pathogenesis; paw edema; phenotype; priority journal; SAPHO syndrome; splenomegaly; swelling; synovitis |
顯示於: | 醫學檢驗暨生物技術學系 |
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