https://scholars.lib.ntu.edu.tw/handle/123456789/504031
標題: | SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos | 作者: | Lin Y.-H. Chou C.-K. Hung Y.-C. Yu I.-S. Pan H.-A. SHU-WHA LIN Kuo P.-L. |
公開日期: | 2011 | 卷: | 95 | 期: | 1 | 起(迄)頁: | 363_365 | 來源出版物: | Fertility and Sterility | 摘要: | Oocytes fertilized with spermatozoa obtained from Septin 12+/- chimeric mice failed to develop beyond the morula stage after IVF and intracytoplasmic sperm injection because of significant DNA defects in the spermatozoa. Given that SEPT12 is expressed at the edge of the sperm nucleus in both humans and mice, we hypothesized the vital roles of Septin 12 in sperm head shaping, nuclear DNA condensation, and early embryonic development. ? 2011 American Society for Reproductive Medicine, Published by Elsevier Inc. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/504031 | ISSN: | 0015-0282 | DOI: | 10.1016/j.fertnstert.2010.07.1064 | SDG/關鍵字: | acridine orange; aniline; cell nucleus DNA; septin; septin 12; tolonium chloride; unclassified drug; animal experiment; article; chimera; controlled study; embryo; embryo development; female; fertilization; human; human cell; human tissue; hypothesis; immunofluorescence test; in vivo study; intracytoplasmic sperm injection; mouse; nonhuman; preimplantation embryo; priority journal; protein expression; sperm; spermatogenesis; spermatozoon; Animals; Cell Nucleus; Embryonic Development; Female; Infertility, Male; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Morula; Pregnancy; Septins; Sperm Head; Sperm Injections, Intracytoplasmic |
顯示於: | 醫學檢驗暨生物技術學系 |
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