Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. Clinical Medicine / 臨床醫學研究所
  4. The WNT2 gene polymorphism associated with speech delay inherent to autism
 
  • Details

The WNT2 gene polymorphism associated with speech delay inherent to autism

Journal
Research in Developmental Disabilities
Journal Volume
33
Journal Volume
33
Journal Issue
5
Journal Issue
5
Pages
1533-1540
Start Page
1533
End Page
1540
ISSN
1873-3379
Date Issued
2012-09
Author(s)
PING-I LIN
YI-LING CHIEN  
YU-YU WU
CHIA-HSIANG CHEN
SUSAN SHUR-FEN GAU  
YU-SHU HAUNG
SHIH-KAI LIU
WEN-CHE TSAI  
YEN-NAN CHIU  
DOI
10.1016/j.ridd.2012.03.004
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860503081&doi=10.1016%2fj.ridd.2012.03.004&partnerID=40&md5=c79611467d68b552fc99772caea32fcc
https://scholars.lib.ntu.edu.tw/handle/123456789/504827
Abstract
Previous evidence suggests that language function is modulated by genetic variants on chromosome 7q31-36. However, it is unclear whether this region harbors loci that contribute to speech delay in autism. We previously reported that the WNT2 gene located on 7q31 was associated with the risk of autism. Additionally, two other genes on 7q31-36, FOXP2 and the EN2 genes are also found to play a role in language impairment. Therefore, we hypothesize that the WNT2 gene, FOXP2 gene, and EN2 gene, may act in concert to influence language development in the same population. A total of 373 individuals diagnosed with autistic disorder were recruited in the current study. We selected 6 tag single nucleotide polymorphisms (SNPs) within the WNT2 gene, 3 tag SNPs in the FOXP2, and 3 tag SNPs in the EN2 genes, to study the effect of these genes on language development. Age of first phrase was treated as a quantitative trait. We used general linear model to assess the association between speech delay and these variants. The results show that rs2896218 in the WNT2 gene was moderately significantly associated with age of first phrase (permutation p=0.0045). A three-locus haplotype in the WNT2 gene was significantly associated with age of first phrase (permutation p=2×10 -4). Furthermore, we detected an interaction effect on age of first phrase between a SNP rs2228946 in the WNT2 gene and another SNP rs6460013 in the EN2 gene (p=0.0012). Therefore, the WNT2 gene may play a suggestive role in language development in autistic disorder. Additionally, the WNT2 gene and EN2 gene may act in concert to influence the language development in autism. ? 2012 Elsevier Ltd.
SDGs

[SDGs]SDG3

Other Subjects
transcription factor FOXP2; Wnt2 protein; age; article; autism; child; disease association; DNA polymorphism; EN2 gene; female; FOXP2 gene; gene; gene function; gene interaction; gene locus; genetic association; genetic variability; haplotype; human; language ability; language disability; major clinical study; male; quantitative trait; school child; single nucleotide polymorphism; speech development; statistical model; WNT2 gene; Adolescent; Age of Onset; Autistic Disorder; Child; Chromosomes, Human, Pair 7; Forkhead Transcription Factors; Haplotypes; Homeodomain Proteins; Humans; Language Development; Language Development Disorders; Linkage Disequilibrium; Nerve Tissue Proteins; Paternal Age; Polymorphism, Single Nucleotide; Wnt2 Protein
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science