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  1. NTU Scholars
  2. 醫學院
  3. 臨床醫學研究所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/504827
DC FieldValueLanguage
dc.contributor.authorLin P.-I.en-US
dc.contributor.authorYI-LING CHIENen-US
dc.contributor.authorWu Y.-Y.en-US
dc.contributor.authorChen C.-H.en-US
dc.contributor.authorGau S.S.F.en-US
dc.contributor.authorHuang Y.-S.en-US
dc.contributor.authorLiu S.-K.en-US
dc.contributor.authorTsai W.-C.en-US
dc.contributor.authorChiu Y.-N.en-US
dc.creatorLin P.-I.;Yi-Ling Chien;Wu Y.-Y.;Chen C.-H.;Gau S.S.F.;Huang Y.-S.;Liu S.-K.;Tsai W.-C.;Chiu Y.-N.-
dc.date.accessioned2020-06-26T02:13:02Z-
dc.date.available2020-06-26T02:13:02Z-
dc.date.issued2012-
dc.identifier.issn0891-4222-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84860503081&doi=10.1016%2fj.ridd.2012.03.004&partnerID=40&md5=c79611467d68b552fc99772caea32fcc-
dc.identifier.urihttps://scholars.lib.ntu.edu.tw/handle/123456789/504827-
dc.description.abstractPrevious evidence suggests that language function is modulated by genetic variants on chromosome 7q31-36. However, it is unclear whether this region harbors loci that contribute to speech delay in autism. We previously reported that the WNT2 gene located on 7q31 was associated with the risk of autism. Additionally, two other genes on 7q31-36, FOXP2 and the EN2 genes are also found to play a role in language impairment. Therefore, we hypothesize that the WNT2 gene, FOXP2 gene, and EN2 gene, may act in concert to influence language development in the same population. A total of 373 individuals diagnosed with autistic disorder were recruited in the current study. We selected 6 tag single nucleotide polymorphisms (SNPs) within the WNT2 gene, 3 tag SNPs in the FOXP2, and 3 tag SNPs in the EN2 genes, to study the effect of these genes on language development. Age of first phrase was treated as a quantitative trait. We used general linear model to assess the association between speech delay and these variants. The results show that rs2896218 in the WNT2 gene was moderately significantly associated with age of first phrase (permutation p=0.0045). A three-locus haplotype in the WNT2 gene was significantly associated with age of first phrase (permutation p=2×10 -4). Furthermore, we detected an interaction effect on age of first phrase between a SNP rs2228946 in the WNT2 gene and another SNP rs6460013 in the EN2 gene (p=0.0012). Therefore, the WNT2 gene may play a suggestive role in language development in autistic disorder. Additionally, the WNT2 gene and EN2 gene may act in concert to influence the language development in autism. ? 2012 Elsevier Ltd.-
dc.relation.ispartofResearch in Developmental Disabilities-
dc.subject.othertranscription factor FOXP2; Wnt2 protein; age; article; autism; child; disease association; DNA polymorphism; EN2 gene; female; FOXP2 gene; gene; gene function; gene interaction; gene locus; genetic association; genetic variability; haplotype; human; language ability; language disability; major clinical study; male; quantitative trait; school child; single nucleotide polymorphism; speech development; statistical model; WNT2 gene; Adolescent; Age of Onset; Autistic Disorder; Child; Chromosomes, Human, Pair 7; Forkhead Transcription Factors; Haplotypes; Homeodomain Proteins; Humans; Language Development; Language Development Disorders; Linkage Disequilibrium; Nerve Tissue Proteins; Paternal Age; Polymorphism, Single Nucleotide; Wnt2 Protein-
dc.subject.other[SDGs]SDG3-
dc.titleThe WNT2 gene polymorphism associated with speech delay inherent to autismen_US
dc.typeJournal Article-
dc.identifier.doi10.1016/j.ridd.2012.03.004-
dc.identifier.pmid22522212-
dc.identifier.scopus2-s2.0-84860503081-
dc.relation.pages1533-1540-
dc.relation.journalvolume33-
dc.relation.journalissue5-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextno fulltext-
crisitem.author.deptPsychiatry-
crisitem.author.deptPsychiatry-NTUH-
crisitem.author.deptCenter for Artificial Intelligence and Advanced Robotics-
crisitem.author.orcid0000-0002-3477-3015-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgResearch Center-
Appears in Collections:臨床醫學研究所
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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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