https://scholars.lib.ntu.edu.tw/handle/123456789/504855
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHIEH-KAI CHAN | en_US |
dc.contributor.author | Hu Y.-H. | en_US |
dc.contributor.author | Chen L. | en_US |
dc.contributor.author | CHIN-CHEN CHANG | en_US |
dc.contributor.author | YU-FENG LIN | en_US |
dc.contributor.author | TAI-SHUAN LAI | en_US |
dc.contributor.author | KUO-HOW HUANG | en_US |
dc.contributor.author | YEN-HUNG LIN | en_US |
dc.contributor.author | VIN-CENT WU | en_US |
dc.contributor.author | KWAN-DUN WU | en_US |
dc.contributor.author | Lin J.-H. | en_US |
dc.contributor.author | Wang W.-J. | en_US |
dc.contributor.author | Wu C.-H. | en_US |
dc.contributor.author | Chang C.-H. | en_US |
dc.contributor.author | Chang Y.-L. | en_US |
dc.contributor.author | Tsai Y.-C. | en_US |
dc.contributor.author | Yu C.-C. | en_US |
dc.contributor.author | Chang H.-W. | en_US |
dc.contributor.author | LIAN-YU LIN | en_US |
dc.contributor.author | Hu F.-C. | en_US |
dc.contributor.author | SHUO-MENG WANG | en_US |
dc.contributor.author | Shih-Cheng Liao | en_US |
dc.contributor.author | CHING-CHU LU | en_US |
dc.contributor.author | RUOH-FANG YEN | en_US |
dc.creator | Chan C.-K.;Hu Y.-H.;Chen L.;Chang C.-C.;Lin Y.-F.;Lai T.-S.;Huang K.-H.;Lin Y.-H.;Wu V.-C.;Wu K.-D.;Lin J.-H.;Wang W.-J.;Wu C.-H.;Chang C.-H.;Chang Y.-L.;Tsai Y.-C.;Yu C.-C.;Chang H.-W.;Lin L.-Y.;Hu F.-C.;Wang S.-M.;Shih-Cheng Liao;Lu C.-C.;Yen R.-F. | - |
dc.date.accessioned | 2020-06-26T03:31:27Z | - |
dc.date.available | 2020-06-26T03:31:27Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1364-8535 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056947969&doi=10.1186%2fs13054-018-2239-y&partnerID=40&md5=2dc42336a34d35b42a296f237c31c419 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/504855 | - |
dc.description.abstract | Background: The interaction between hyperaldosteronism and immune dysfunction has been reported and glucocorticoid co-secretion is frequently found in primary aldosteronism (PA). The aforementioned conditions raise the possibility of the infection risk; however, clinical episodes of sepsis have not been reported in PA. Methods: Using Taiwan's National Health Insurance Research Database between 1997 and 2009, we identified PA and aldosterone-producing adenoma (APA) matched with essential hypertension (EH) at a 1:1 ratio by propensity scores. The incidences of sepsis and mortality after the index date were evaluated, and the risk factors of outcomes were identified using adjusted Cox proportional hazards models and taking mortality as a competing risk. Results: We enrolled 2448 patients with PA (male, 46.08%; mean age, 48.4 years). There were 875 patients who could be ascertained as APA. Taking mortality as the competing risk, APA patients had a lower incidence of sepsis than their matched EH patients (hazard ratio (HR) 0.29; P < 0.001) after target treatments. Patients receiving adrenalectomy showed a benefit of decreasing the risk of sepsis (PA vs EH, HR 0.14, P = 0.001; APA vs EH, HR 0.16, P = 0.003), but mineralocorticoid receptor antagonist treatment may differ. Compared with matched control cohorts, patients with APA had a lower risk of all-cause mortality (PA, adjusted HR 0.84, P = 0.050; APA, adjusted HR 0.31, P < 0.001) after target treatments. Conclusions: Our study demonstrated that patients with PA/APA who underwent adrenalectomy could attenuate the risk of sepsis compared with their matched EH patients. We further found that APA patients with target treatments could decrease all-cause mortality compared with EH patients. ? 2018 The Author(s). | en_US |
dc.publisher | BioMed Central Ltd. | en_US |
dc.relation.ispartof | Critical Care | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | angiotensin receptor antagonist; anticoagulant agent; beta adrenergic receptor blocking agent; calcium channel blocking agent; dipeptidyl carboxypeptidase inhibitor; inotropic agent; mineralocorticoid antagonist; nonsteroid antiinflammatory agent; adenoma; adrenalectomy; adult; Article; attenuation; Charlson Comorbidity Index; clinical outcome; cohort analysis; controlled study; death; essential hypertension; female; hazard ratio; human; hypertension; ICD-9-CM; incidence; infection risk; intermethod comparison; major clinical study; male; middle aged; mortality; primary hyperaldosteronism; priority journal; propensity score; proportional hazards model; risk factor; sepsis; septic shock; static group comparison; complication; hyperaldosteronism; pathophysiology; procedures; risk assessment; sepsis; Taiwan; Adrenalectomy; Adult; Female; Humans; Hyperaldosteronism; Incidence; Male; Middle Aged; Propensity Score; Risk Assessment; Risk Factors; Sepsis; Taiwan | - |
dc.title | Risk of sepsis in patients with primary aldosteronism | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1186/s13054-018-2239-y | - |
dc.identifier.pmid | 30463626 | - |
dc.identifier.scopus | 2-s2.0-85056947969 | - |
dc.relation.pages | 313 | en_US |
dc.relation.journalvolume | 22 | en_US |
dc.relation.journalissue | 1 | en_US |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Forensic Medicine | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Surgical Oncology-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Master's Program in Smart Medicine and Health Informatics (SMARTMHI) | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUHHC | - |
crisitem.author.dept | Urology-NTUHBH | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Psychiatry-NTUHHC | - |
crisitem.author.dept | Nuclear Medicine-NTUH | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Nuclear Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-4529-3161 | - |
crisitem.author.orcid | 0000-0002-0121-4866 | - |
crisitem.author.orcid | 0000-0002-4350-7755 | - |
crisitem.author.orcid | 0000-0002-0552-372X | - |
crisitem.author.orcid | 0000-0002-0989-0578 | - |
crisitem.author.orcid | 0000-0001-8153-1441 | - |
crisitem.author.orcid | 0000-0001-7935-0991 | - |
crisitem.author.orcid | 0000-0002-3339-1509 | - |
crisitem.author.orcid | 0000-0001-7505-6429 | - |
crisitem.author.orcid | 0000-0003-2090-1757 | - |
crisitem.author.orcid | 0000-0003-4129-0879 | - |
crisitem.author.orcid | 0000-0003-3114-582X | - |
crisitem.author.orcid | 0000-0003-1648-6482 | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | International College | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Bei-Hu Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
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