https://scholars.lib.ntu.edu.tw/handle/123456789/506285
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yeh H.-P. | en_US |
dc.contributor.author | Huang Y.-C. | en_US |
dc.contributor.author | LI-YING WANG | en_US |
dc.contributor.author | Shueng P.-W. | en_US |
dc.contributor.author | Tien H.-J. | en_US |
dc.contributor.author | Chang C.-H. | en_US |
dc.contributor.author | Chou S.-F. | en_US |
dc.contributor.author | Hsieh C.-H. | en_US |
dc.creator | Yeh H.-P.;Huang Y.-C.;Li-Ying Wang;Shueng P.-W.;Tien H.-J.;Chang C.-H.;Chou S.-F.;Hsieh C.-H. | - |
dc.date.accessioned | 2020-06-29T02:20:06Z | - |
dc.date.available | 2020-06-29T02:20:06Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1748-880X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082145909&doi=10.1259%2fbjr.20190792&partnerID=40&md5=3c1ca91569c1e0b55a5ab40e89eb5688 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/506285 | - |
dc.description.abstract | Objectives: To evaluate the feasibility and optimal restricted angle of the complete-directional- complete block (CDCB) technique in helical tomotherapy (HT) by including regional nodal irradiation (RNI) with the internal mammary node (IMN) in left-sided breast cancer. Methods: Ten left-sided breast cancer patients treated with 50 Gy in 25 fractions were compared with five-field intensity-modulated radiation therapy (5F-IMRT) and six types of HT plans. In the HT plans, complete block (CB), organ-based directional block (OBDB) and CDCB with different restricted angles were used. Results: The conformity index (CI) between the CDCB0,10,15,20 and 5F-IMRT groups was similar. Compared to CB, OBDB and 5F-IMRT, CDCB20 resulted in a decreased ipsilateral mean lung dose. The low-dose region (V5) of the ipsilateral lung in OBDB (84.0%) was the highest among all techniques (p < 0.001). The mean dose of the heart in CB was significantly reduced (by 11.5-22.4%) compared with other techniques. The V30 of the heart in CDCB20 (1.9%) was significantly lower than that of CB, OBDB and 5F-IMRT. Compared to the mean dose of the left anterior descending (LAD) artery of 5F-IMRT (27.0 Gy), CDCB0, CDCB10, CDCB15, CDCB20 and OBDB reduced the mean dose effectively by 31.7%, 38.3%, 39.6%, 42.0 and 56.2%, respectively. Considering the parameters of the organs-at- risk (OARs), CDCB10,15,20 had higher expectative values than the other techniques (p = 0.01). Conclusions: HT with the CDCB technique is feasible for treating left-sided breast cancer patients. The CDCB10- 20 techniques not only achieved similar planning target volume coverage, homogeneity and dose conformity but also allowed better sparing of the heart and bilateral lungs. ? 2020 The Authors. | - |
dc.publisher | NLM (Medline) | - |
dc.relation.ispartof | The British journal of radiology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | breast tumor; diagnostic imaging; feasibility study; female; heart; human; intensity modulated radiation therapy; lung; organs at risk; procedures; radiation injury; radiation response; radiotherapy; radiotherapy planning system; Dose Fractionation, Radiation; Feasibility Studies; Female; Heart; Humans; Lung; Lymphatic Irradiation; Organs at Risk; Radiation Injuries; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated; Unilateral Breast Neoplasms | - |
dc.title | Helical tomotherapy with a complete-directional-complete block technique effectively reduces cardiac and lung dose for left-sided breast cancer | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1259/bjr.20190792 | - |
dc.identifier.pmid | 31939310 | - |
dc.identifier.scopus | 2-s2.0-85082145909 | - |
dc.relation.journalvolume | 93 | - |
dc.relation.journalissue | 1108 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Physical Therapy | - |
crisitem.author.orcid | 0000-0003-3075-6872 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 物理治療學系所 |
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