https://scholars.lib.ntu.edu.tw/handle/123456789/506302
Title: | Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging | Authors: | Hsieh L.-C. Chen J.W. LI-YING WANG Tsang Y.-M. Shueng P.-W. Liao L.-J. Lo W.-C. Lin Y.-C. Tseng C.-F. Kuo Y.-S. Jhuang J.-Y. Tien H.-J. Juan H.-F. Hsieh C.-H. |
Issue Date: | 2014 | Publisher: | Public Library of Science | Journal Volume: | 9 | Journal Issue: | 3 | Start page/Pages: | e92561 | Source: | PLoS ONE | Abstract: | To develop magnetic resonance imaging (MRI) indicators to predict trismus outcome for post-operative oral cavity cancer patients who received adjuvant intensity-modulated radiation therapy (IMRT), 22 patients with oral cancer treated with IMRT were studied over a two-year period. Signal abnormality scores (SA scores) were computed from Likert-type ratings of the abnormalities of nine masticator structures and compared with the Mann-Whitney U-test and Kruskal-Wallis one-way ANOVA test between groups. Seventeen patients (77.3%) experienced different degrees of trismus during the two-year follow-up period. The SA score correlated with the trismus grade (r = 0.52, p<0.005). Patients having progressive trismus had higher mean doses of radiation to multiple structures, including the masticator and lateral pterygoid muscles, and the parotid gland (p<0.05). In addition, this group also had higher SA-masticator muscle dose product at 6 months and SA scores at 12 months (p<0.05). At the optimum cut-off points of 0.38 for the propensity score, the sensitivity was 100% and the specificity was 93% for predicting the prognosis of the trismus patients. The SA score, as determined using MRI, can reflect the radiation injury and correlate to trismus severity. Together with the radiation dose, it could serve as a useful biomarker to predict the outcome and guide the management of trismus following radiation therapy. ? 2014 Hsieh et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899093143&doi=10.1371%2fjournal.pone.0092561&partnerID=40&md5=c2fd946d5454e6d783e1554df36ae390 https://scholars.lib.ntu.edu.tw/handle/123456789/506302 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0092561 | SDG/Keyword: | adjuvant therapy; adult; aged; article; clinical article; disease association; disease severity; female; follow up; human; intensity modulated radiation therapy; male; masticatory muscle; mouth cancer; nuclear magnetic resonance imaging; outcome assessment; parotid gland; prognosis; radiation dose; radiation injury; radiological parameters; sensitivity and specificity; signal abnormality score; trismus; Carcinoma, Squamous Cell; intensity modulated radiation therapy; Mouth Neoplasms; nuclear magnetic resonance imaging; pathology; procedures; prognosis; Radiation Injuries; radiation response; retrospective study; trismus; Carcinoma, Squamous Cell; Dose-Response Relationship, Radiation; Humans; Magnetic Resonance Imaging; Masticatory Muscles; Mouth Neoplasms; Prognosis; Radiation Injuries; Radiotherapy, Intensity-Modulated; Retrospective Studies; Trismus |
Appears in Collections: | 物理治療學系所 |
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