https://scholars.lib.ntu.edu.tw/handle/123456789/506303
Title: | Clinical effectiveness, toxicity, and failure patterns of helical tomotherapy for postoperative oral cavity cancer patients | Authors: | Hsieh C.-H. Shueng P.-W. LI-YING WANG Liao L.-J. Lin Y.-C. Kuo Y.-S. Lo W.-C. Tseng C.-F. Tien H.-J. Chou H.-L. Hsieh Y.-P. Wu L.-J. Chen Y.-J. |
Issue Date: | 2014 | Publisher: | DOVE Medical Press Ltd. | Journal Volume: | 7 | Start page/Pages: | 405-414 | Source: | OncoTargets and Therapy | Abstract: | Background: The outcome of postoperative high- and intermediate-risk oral cavity cancer (OCC) patients receiving helical tomotherapy (HT) remains limited. Materials and methods: Between November 2006 and November 2012, 53 postoperative high- and intermediate-risk OCC patients treated with HT were enrolled. Results: The 4-year locoregional, local, and regional control rates were 66%, 76.4%, and 94.3%, respectively. The 4-year locoregional control rates of oral tongue and buccal mucosa cancer were 88.3% and 37.1%, respectively (P=0.012). Eleven (20.8%) patients experienced locoregional failure. In-field failure occurred in six of 53 (11.3%) in the primary area and three of 53 (5.7%) in the regional lymph-node area. No marginal failure was noted. Two of 53 (3.8%) experienced out-of-field failure. The rates of grade 3 dermatitis, mucositis, and dysphagia were 11%, 34%, and 13%, respectively. No grade 3 xerostomia was noted. Grade 2 xerostomia was 33% at month 6 and declined to 0 at month 48. A rate of 56% of grade 2 trismus at month 6 was noted, and declined to around 30% after 2 years. No grade 3 trismus was noted after 2 years. Conclusion: HT as a postoperative modality provided satisfying results, especially for xerostomia and trismus, and was impressive in high- and intermediate-risk OCC patients receiving postoperative HT. ? 2014 Hsieh et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84897903834&doi=10.2147%2fOTT.S59998&partnerID=40&md5=d620021f6291eed4e8e170e665261f24 https://scholars.lib.ntu.edu.tw/handle/123456789/506303 |
ISSN: | 1178-6930 | DOI: | 10.2147/OTT.S59998 | SDG/Keyword: | cisplatin; fluorouracil; folinic acid; adult; aged; anemia; article; cancer control; cancer radiotherapy; cheek mucosa; chemoradiotherapy; dysphagia; female; fistula; human; leukopenia; major clinical study; male; mouth squamous cell carcinoma; mucosa inflammation; oral surgery; photon therapy; postoperative care; radiation dermatitis; retrospective study; therapy effect; thrombocytopenia; tomotherapy; tongue cancer; treatment failure; trismus; xerostomia |
Appears in Collections: | 物理治療學系所 |
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