https://scholars.lib.ntu.edu.tw/handle/123456789/507174
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | KUO-CHU CHANG | en_US |
dc.contributor.author | Hsu K.-L. | en_US |
dc.contributor.author | Chou T.-F. | en_US |
dc.contributor.author | Lo H.-M. | en_US |
dc.contributor.author | Tseng Y.-Z. | en_US |
dc.creator | Kuo-Chu Chang;Hsu K.-L.;Chou T.-F.;Lo H.-M.;Tseng Y.-Z. | - |
dc.date.accessioned | 2020-06-30T07:47:04Z | - |
dc.date.available | 2020-06-30T07:47:04Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0007-1188 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-4143091435&doi=10.1038%2fsj.bjp.0705831&partnerID=40&md5=1470ff1b179e4fb186532c461184541e | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/507174 | - |
dc.description.abstract | 1. In recent studies, aminoguanidine (AG), an inhibitor of advanced glycation endproducts, has been identified as a prominent agent that can prevent the age-related aortic stiffening and cardiac hypertrophy. The aim of this study was to determine whether AG had effects on the left ventricular (LV)-arterial coupling in aged Fisher 344 rats in terms of the ventricular and arterial chamber properties. 2. Normotensive rats were treated from 18 to 24 months with AG (1 gl -1 in drinking water) and compared with a control group. LV pressure and ascending aortic flow signals were recorded to construct the ventricular and arterial end-systolic pressure-stroke volume relationships to calculate LV end-systolic elastance (E es) and effective arterial volume elastance (E a), respectively. The optimal afterload (Q load) determined by the ratio of E a to E es was used to measure the efficiency of mechanical energy transferred from the left ventricle to the arterial system. 3. In comparison with the 6-month-old rats, the 24-month-old animals had decreased E es, at 567.4±26.7 vs 639.0±20.7 mmHg ml -1, decreased E a, at 411.5±18.6 vs 577.9±15.7 mmHg ml -1, and decreased Q load, at 0.9428±0.0024 vs 0.9962±0.0014. 4. Treatment with AG for 6 months did not significantly affect E es; however, when normalized to LV weight (i.e., E esn = E es/LV weight), E esn showed a significant rise of 22.8%, suggesting that AG may retard the aging process on the intrinsic contractility of the left ventricle. On the other hand, the decrease in E a in aging rats was prevented by AG, as reflected in the increase of 19.7% in this variable (P<0.05). The 24-month-old treated rats also exhibited a significant rise of 21.6% in E a/E es, causing an increase of 5.2% in Q load (P<0.05). 5. We conclude that in healthy older Fisher 344 rats without diabetes, long-term treatment with AG may improve both the arterial and ventricular function and optimize the matching condition for the left ventricular-arterial coupling. | - |
dc.relation.ispartof | British Journal of Pharmacology | - |
dc.subject | Aminoguanidine; Effective arterial volume elastance; Left ventricular end-systolic elastance; Left ventricular-arterial coupling; Optimal afterload | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | aminoguanidine; age; aging; animal experiment; animal model; aorta flow; arteriosclerosis; artery; artery compliance; article; controlled study; glycation; heart afterload; heart disease; heart left ventricle; heart left ventricle contractility; heart left ventricle pressure; heart stroke volume; heart ventricle compliance; heart ventricle hypertrophy; hemodynamic parameters; long term exposure; male; nonhuman; priority journal; rat; rat strain; systolic blood pressure; Aging; Animals; Blood Pressure; Coronary Vessels; Glycosylation End Products, Advanced; Guanidines; Heart; Male; Rats; Rats, Inbred F344; Ventricular Function, Left; Ventricular Pressure | - |
dc.title | Aminoguanidine prevents age-related deterioration in left ventricular-arterial coupling in Fisher 344 rats | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/sj.bjp.0705831 | - |
dc.identifier.pmid | 15249427 | - |
dc.identifier.scopus | 2-s2.0-4143091435 | - |
dc.relation.pages | 1099-1104 | - |
dc.relation.journalvolume | 142 | - |
dc.relation.journalissue | 7 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Physiology | - |
crisitem.author.orcid | 0000-0002-4421-5711 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 生理學科所 |
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