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  4. Impaired vascular dynamics in normotensive diabetic rats induced by streptozotocin: Tapered T-tube model analysis
 
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Impaired vascular dynamics in normotensive diabetic rats induced by streptozotocin: Tapered T-tube model analysis

Journal
Journal of Theoretical Biology
Journal Volume
204
Journal Issue
3
Pages
371-380
Date Issued
2000
Author(s)
KUO-CHU CHANG  
Chen T.-J.
Peng Y.-I.
Li T.-H.
Tseng Y.-Z.
DOI
10.1006/jtbi.2000.2021
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034616615&doi=10.1006%2fjtbi.2000.2021&partnerID=40&md5=adc474fd7823cdfef30240f544e30149
https://scholars.lib.ntu.edu.tw/handle/123456789/507182
Abstract
This study is to explore the changes of arterial mechanical properties in streptozotocin (STZ)-diabetic rats, based on the exponentially tapered T-tube model. Rats given STZ 65 mg kg-1 i.v. are compared with untreated weight- and age-matched controls. A high-fidelity pressure sensor and electromagnetic flow probe measured pulsatile pressure and flow waves in the ascending aorta, respectively. Diabetic rats exhibit isobaric vasodilatation that is characterized by an increase in cardiac output and no significant changes in aortic pressure. Total peripheral resistance of diabetic rats is lower than that of weight- and age-matched controls. Diabetic rats have higher total peripheral compliance (2.86 ± 0.70 μl mmHg-1) than do weight- (1.77 ± 0.34 μl mmHg-1) and age-matched (1.87 ± 0.69 μl mmHg-1) controls. Aortic characteristic impedance is reduced from 0.017 ± 0.003 mmHg min kg ml-1 in weight- and 0.020 ± 0.004 mmHg min kg ml-1 in age-matched controls to 0.010 ± 0.004 mmHg min kg ml-1 in diabetic rats. Moreover, diabetic rats show shorter wave transit time in lower body circulation (17.86 ± 1.91 ms) than do weight- (20.45 ± 1.91) and age-matched (23.05 ± 2.04 ms) controls. Under isobaric vasodilatation, the decreased resistance and increased compliance in peripheral circulation suggest that the contractile dysfunction of the smooth muscle cells may occur in resistance arterioles in diabetes. With unaltered aortic pressure, an impairment in aortic distensibility of STZ-diabetic rats is manifest on the reduced wave transit time rather than on the diminished aortic characteristic impedance. (C) 2000 Academic Press.
SDGs

[SDGs]SDG3

Other Subjects
animal experiment; animal model; aorta pressure; article; controlled study; electromagnetic field; heart output; hemodynamics; male; model; nonhuman; priority journal; pulse pressure; rat; streptozocin diabetes; vascular resistance; vasodilatation; Animalia
Publisher
Academic Press
Type
journal article

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