Low-dose paeonol derivatives alleviate lipid accumulation
Journal
RSC Advances
Journal Volume
5
Journal Issue
8
Pages
5652-5656
Date Issued
2015
Author(s)
Abstract
Here, we present a series of novel paeonol derivatives that prevent lipid accumulation at lower doses and exhibit improved water solubility. According to SAR analysis results, 1-(4-methoxy-2-(2-(piperidin-1-yl)ethoxy)phenyl)ethanone (6a) and 4′-methoxy-2′-[(phenylsulfonyl)oxy]acetophenone (7a) demonstrate as good inhibition ability at low-dose (10 μg mL-1) as that of paeonol at high-dose (100 μg mL-1). In addition, compounds 6a and 7a can be synthesized quantitatively with simple preparation methods. Hence, we believe that compounds 6a and 7a are potentially suitable antiatherogenic compounds for future drug development. This journal is
Publisher
Royal Society of Chemistry
Type
journal article