https://scholars.lib.ntu.edu.tw/handle/123456789/507646
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wang C.-C. | en_US |
dc.contributor.author | Fu C.-L. | en_US |
dc.contributor.author | YAO-HSU YANG | en_US |
dc.contributor.author | Lo Y.-C. | en_US |
dc.contributor.author | LI-CHIEH WANG | en_US |
dc.contributor.author | YA-HUI CHUANG | en_US |
dc.contributor.author | Chang D.-M. | en_US |
dc.contributor.author | BOR-LUEN CHIANG | en_US |
dc.creator | Wang C.-C.;Fu C.-L.;Yang Y.-H.;Lo Y.-C.;Wang L.-C.;Ya-Hui Chuang;Chang D.-M.;Chiang B.-L. | - |
dc.date.accessioned | 2020-07-01T06:55:07Z | - |
dc.date.available | 2020-07-01T06:55:07Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0969-7128 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/507646 | - |
dc.description.abstract | Interleukin-1 (IL-1) is a proinflammatory cytokine and IL-1 receptor antagonist (IL-1ra) is a natural inhibitor that binds to IL-1 receptor type I without inducing signal transduction. It is suggested that IL-1 is required for allergen-specific T helper type 2 cell activation and the development of airway hyper-responsiveness (AHR), but the immunologic effect of exogenous IL-1ra in allergic asthma remains unclear. To examine the effect of IL-1ra on airway inflammation and immunoeffector cells in allergic asthma, recombinant adenovirus expressing human IL-1ra (Ad-hIL-1ra) was delivered intranasally into ovalbumin (OVA)-immunized mice. Single intranasal administration of Ad-hIL-1ra before airway antigen challenge in OVA-immunized mice significantly decreased the severity of AHR and reduced pulmonary infiltration of eosinophils and neutrophils. Suppression of IL-5 and eotaxin with concomitant enhancement of interferon gamma in bronchoalveolar lavage fluid was also noted in OVA-immunized mice by administration of Ad-hIL-1ra. In addition, histological studies showed that Ad-hIL-1ra was able to decrease OVA-induced peribronchial inflammation. Taken together, our results indicated that administration of Ad-hIL-1ra may have therapeutic potential for the immunomodulatory treatment of allergic asthma. | - |
dc.relation.ispartof | Gene Therapy | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adenovirus vector; eotaxin; gamma interferon; interleukin 1 receptor blocking agent; interleukin 5; ovalbumin; allergic asthma; animal experiment; animal model; animal tissue; antiinflammatory activity; article; controlled study; disease severity; drug megadose; eosinophil; female; gene expression; histopathology; immunomodulation; low drug dose; lung infiltrate; lung lavage; mouse; neutrophil chemotaxis; nonhuman; priority journal; viral gene delivery system; viral gene therapy; virus recombinant; Adenoviridae; Administration, Inhalation; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Chemokine CCL11; Chemokines, CC; Female; Gene Therapy; Genetic Engineering; Genetic Vectors; Hypersensitivity; Interferon Type II; Interferon-gamma; Interleukin 1 Receptor Antagonist Protein; Interleukin-5; Lung; Mice; Mice, Inbred BALB C; Models, Animal; Ovalbumin; Th2 Cells; Transduction, Genetic; Adenoviridae; Murinae | - |
dc.title | Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/sj.gt.3302798 | - |
dc.identifier.pmid | 16724092 | - |
dc.identifier.scopus | 2-s2.0-33748879109 | - |
dc.relation.pages | 1414-1421 | - |
dc.relation.journalvolume | 13 | - |
dc.relation.journalissue | 19 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | College of Life Science | - |
crisitem.author.dept | Immunology | - |
crisitem.author.orcid | 0000-0002-6266-9864 | - |
crisitem.author.orcid | 0000-0002-5773-1627 | - |
crisitem.author.orcid | 0000-0003-0857-0035 | - |
crisitem.author.orcid | 0000-0002-6705-0286 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學檢驗暨生物技術學系 |
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