https://scholars.lib.ntu.edu.tw/handle/123456789/507745
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Sher Y.-P. | en_US |
dc.contributor.author | Wang L.-J. | en_US |
dc.contributor.author | Chuang L.-L. | en_US |
dc.contributor.author | Tsai M.-H. | en_US |
dc.contributor.author | Kuo T.-T. | en_US |
dc.contributor.author | Huang C.-C. | en_US |
dc.contributor.author | Chuang E.Y. | en_US |
dc.contributor.author | LIANG-CHUAN LAI | en_US |
dc.creator | Sher Y.-P.;Wang L.-J.;Chuang L.-L.;Tsai M.-H.;Kuo T.-T.;Huang C.-C.;Chuang E.Y.;Liang-Chuan Lai | - |
dc.date.accessioned | 2020-07-01T08:12:25Z | - |
dc.date.available | 2020-07-01T08:12:25Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899465786&doi=10.1371%2fjournal.pone.0094065&partnerID=40&md5=5e8eb1031959722d2660290106a5da15 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/507745 | - |
dc.description.abstract | Lung cancer is the leading cause of cancer death worldwide, and brain metastasis is a major cause of morbidity and mortality in lung cancer. CDH2 (N-cadherin, a mesenchymal marker of the epithelial-mesenchymal transition) and ADAM9 (a type I transmembrane protein) are related to lung cancer brain metastasis; however, it is unclear how they interact to mediate this metastasis. Because microRNAs regulate many biological functions and disease processes (e.g., cancer) by down-regulating their target genes, microRNA microarrays were used to identify ADAM9-regulated miRNAs that target CDH2 in aggressive lung cancer cells. Luciferase assays and western blot analysis showed that CDH2 is a target gene of miR-218. MiR-218 was generated from pri-mir-218-1, which is located in SLIT2, in non-invasive lung adenocarcinoma cells, whereas its expression was inhibited in aggressive lung adenocarcinoma. The down-regulation of ADAM9 up-regulated SLIT2 and miR-218, thus down-regulating CDH2 expression. This study revealed that ADAM9 activates CDH2 through the release of miR-218 inhibition on CDH2 in lung adenocarcinoma. ? 2014 Sher et al. | - |
dc.publisher | Public Library of Science | - |
dc.relation.ispartof | PLoS ONE | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | ADAM9 protein; membrane protein; microRNA; microRNA 218; nerve cell adhesion molecule; unclassified drug; 3' untranslated region; ADAM protein; ADAM9 protein, human; cadherin; CDH2 protein, human; leukocyte antigen; membrane protein; microRNA; MIRN218 microRNA, human; ADAM9 gene; article; brain metastasis; carcinoma cell; CDH2 gene; controlled study; down regulation; gene; gene control; gene repression; gene targeting; human; human cell; luciferase assay; lung adenocarcinoma; microarray analysis; morbidity; mortality; nucleotide sequence; upregulation; Western blotting; 3' untranslated region; adenocarcinoma; binding site; cell motion; chemistry; cluster analysis; gene expression profiling; gene expression regulation; genetics; lung tumor; metabolism; nucleotide sequence; pathology; RNA interference; transcription initiation; tumor cell line; 3' Untranslated Regions; ADAM Proteins; Adenocarcinoma; Antigens, CD; Base Sequence; Binding Sites; Cadherins; Cell Line, Tumor; Cell Movement; Cluster Analysis; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Membrane Proteins; MicroRNAs; RNA Interference; Transcriptional Activation | - |
dc.title | ADAM9 up-regulates N-cadherin via miR-218 suppression in lung adenocarcinoma cells | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1371/journal.pone.0094065 | - |
dc.identifier.pmid | 24705471 | - |
dc.identifier.scopus | 2-s2.0-84899465786 | - |
dc.relation.pages | e94065 | - |
dc.relation.journalvolume | 9 | - |
dc.relation.journalissue | 4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Physiology | - |
crisitem.author.orcid | 0000-0002-3913-5338 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 生理學科所 |
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