https://scholars.lib.ntu.edu.tw/handle/123456789/508007
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Hsu C.-H. | en_US |
dc.contributor.author | CHUN-YI LU | en_US |
dc.contributor.author | PEI-LAN SHAO | en_US |
dc.contributor.author | PING-ING LEE | en_US |
dc.contributor.author | CHUAN-LIANG KAO | en_US |
dc.contributor.author | Chung M.-Y. | en_US |
dc.contributor.author | LUAN-YIN CHANG | en_US |
dc.contributor.author | LI-MIN HUANG | en_US |
dc.creator | Hsu C.-H. ;Lu C.-Y. ;Shao P.-L. ;Lee P.-I. ;Chuan-Liang Kao ;Chung M.-Y. ;Chang L.-Y. ;Huang L.-M. | - |
dc.date.accessioned | 2020-07-03T02:18:23Z | - |
dc.date.available | 2020-07-03T02:18:23Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/508007 | - |
dc.description.abstract | Background: Non-polio enteroviruses may cause different diseases, including herpangina, hand-foot-mouth disease (HFMD), meningitis, and nonspecific febrile illness; and cause epidemic outbreak annually. This study delineates the diversity of clinical presentations based on different serotypes and different groups [human enterovirus (HEV)-A and HEV-B] of enteroviruses (EVs) during the 2008 epidemic in National Taiwan University Hospital (NTUH). Methods: We retrospectively identified patients younger than 18 years who had positive isolates of non-polio EV in throat swabs, rectal swabs, or cerebrospinal fluid, in NTUH from January 1 to December 31, 2008. For serotyping, immunofluorescence assay and polymerase chain reaction followed by viral structure protein-1 sequencing were applied. We analyzed and compared their clinical features among different serotypes and different groups of EVs. Results: Among 172 patients who were enrolled, 16 serotypes were identified. The major serotype in NTUH was EV71 (25.6%) followed by coxsackievirus A (CA)16 and coxsackievirus B (CB)4. EV71 manifested mostly as HFMD (89%) and was complicated with encephalomyelitis in three patients. Serotypes of HFMD included EV71 (70%), CA16 (27%), CA4, and CA6. Serotypes of herpangina were heterogeneous, and the major serotype was CA2 (35.7%) followed by CB4 (23.8%). Aseptic meningitis was entirely caused by HEV-B and mostly infected by echovirus 30 (50%). Among children with EV-related respiratory tract infection, CB4 (32%) was dominant in upper respiratory tract infection, whereas echovirus 4 (71%) was the major cause of lower respiratory tract infection. Cases of HEV-A were significantly younger than the cases of HEV-B (p = 0.04). Multivariate analysis revealed that the most significant factor associated with hospitalization is HEV-B (odds ratio, 2.2; 95% confidence interval, 1.1-4.2; p = 0.02). Conclusions: At least 16 serotypes circulated in northern Taiwan in 2008. EV71 is the predominant strain in this outbreak. All patients with HFMD were infected by HEV-A, but HEV-B was associated with a higher rate of hospitalization and aseptic meningitis, which should be a cause of alert regarding public health. ? 2011. | - |
dc.relation.ispartof | Journal of Microbiology, Immunology and Infection | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | coxsackie virus and adenovirus receptor; article; aseptic meningitis; cerebrospinal fluid; child; clinical feature; controlled study; disease association; Enterovirus infection; female; herpangina; hospitalization; human; immunofluorescence; lower respiratory tract infection; major clinical study; male; nonhuman; polymerase chain reaction; retrospective study; serotype; Taiwan; throat culture; Adolescent; Chi-Square Distribution; Child; Child, Preschool; Enterovirus; Enterovirus Infections; Female; Fluorescent Antibody Technique; Hospitalization; Hospitals, University; Humans; Infant; Male; Multivariate Analysis; Phylogeny; Polymerase Chain Reaction; Retrospective Studies; Serotyping; Taiwan | - |
dc.title | Epidemiologic and clinical features of non-polio enteroviral infections in northern Taiwan in 2008 | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jmii.2011.01.029 | - |
dc.identifier.pmid | 21524954 | - |
dc.identifier.scopus | 2-s2.0-79959561466 | - |
dc.relation.pages | 265-273 | - |
dc.relation.journalvolume | 44 | - |
dc.relation.journalissue | 4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Pediatrics-NTUHHC | - |
crisitem.author.dept | Laboratory Medicine-NTUHHC | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | National Taiwan University Children's Hospital | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.orcid | 0000-0002-5240-2808 | - |
crisitem.author.orcid | 0000-0003-3334-1330 | - |
crisitem.author.orcid | 0000-0002-7299-2825 | - |
crisitem.author.orcid | 0000-0002-1020-2605 | - |
crisitem.author.orcid | 0000-0003-2632-1956 | - |
crisitem.author.orcid | 0000-0002-9291-260X | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學檢驗暨生物技術學系 |
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