https://scholars.lib.ntu.edu.tw/handle/123456789/508163
Title: | Host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung disease | Authors: | CHIN-CHUNG SHU Wu M.-F. Pan S.-W. Wu T.-S. HSIN-CHIH LAI Lin M.-C. |
Issue Date: | 2020 | Source: | Journal of the Formosan Medical Association | Abstract: | Nontuberculous mycobacterial lung disease (NTM-LD) prevalence has been increasing over the recent decades. Numerous host factors are associated with NTM-LD development, including susceptible phenotypes such as ciliary defect and lung structural change, pulmonary clearance defect with poor clearance of secretions, and immune suppression. Specifically, regarding the susceptible host phenotypes without clear pathogenesis, a slender body, pectus excavatum, and postmenopausal female status are common. Also, decreased host immunity to NTM, especially T helper 1 cell responses is frequently observed. Even so, the underlying mechanisms remain unclear and relevant large-scale studies are lacking. Infections due to host genetics associated defects are mostly untreatable but rare in Asia, particularly Taiwan. Nevertheless, some risks for NTM-LD are controllable over disease progression. We suggest that clinicians first manage host factors and deal with the controllable characteristics of NTM-LD, followed by optimizing anti-NTM treatment. Further researches focusing on NTM-LD pathogenesis, especially the host–NTM interaction may advance understanding the nature of the disease and develop efficient therapeutic regimens. ? 2020 Formosan Medical Association |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/508163 | ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2020.05.001 | SDG/Keyword: | host factor; atypical mycobacteriosis; atypical Mycobacterium; bronchiectasis; ciliated epithelium; congenital disorder; controlled study; cystic fibrosis; disease exacerbation; female; funnel chest; gastrointestinal reflux; genetics; host susceptibility; human; immune deficiency; immune response; immunity; immunocompetent cell; immunosuppressive treatment; lung clearance; lung disease; macrophage; nonhuman; pathogenesis; phenotype; postmenopause; prevalence; respiratory system; Review; Th1 cell; Asia; atypical mycobacteriosis; immunity; immunology; male; risk factor; Taiwan; Asia; Female; Humans; Immunity; Male; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Postmenopause; Risk Factors; Taiwan |
Appears in Collections: | 醫學檢驗暨生物技術學系 |
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