https://scholars.lib.ntu.edu.tw/handle/123456789/508208
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHIN-CHUNG SHU | en_US |
dc.contributor.author | JANN-YUAN WANG | en_US |
dc.contributor.author | CHIA-LIN HSU | en_US |
dc.contributor.author | LI-TA KENG | en_US |
dc.contributor.author | Tsui K. | en_US |
dc.contributor.author | Lin J.-F. | en_US |
dc.contributor.author | HSIN-CHIH LAI | en_US |
dc.contributor.author | CHONG-JEN YU | en_US |
dc.contributor.author | LI-NA LEE | en_US |
dc.contributor.author | KWEN-TAY LUH | en_US |
dc.creator | Shu C.-C.;Wang J.-Y.;Hsu C.-L.;Keng L.-T.;Tsui K.;Lin J.-F.;Hsin-Chih Lai;Yu C.-J.;Lee L.-N.;Luh K.-T. | - |
dc.date.accessioned | 2020-07-03T04:00:36Z | - |
dc.date.available | 2020-07-03T04:00:36Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1323-7799 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/508208 | - |
dc.description.abstract | Background and objective Early diagnosis of tuberculous pleural effusion (TPE) remains difficult. While some inflammatory markers in pleural effusion (PE) are helpful in diagnosis, the roles of anti-inflammatory cytokines and effector molecules of cytotoxic T lymphocytes have not been investigated. Methods Lymphocyte-predominant exudative PE samples were assayed for inflammatory and anti-inflammatory cytokines and effector molecules of cytotoxic T lymphocytes. Logistic regression analysis was used to predict the probability of TPE and identify independently associated factors. Receiver operating characteristic (ROC) curve analysis was applied to determine the optimal cut-off value for the predicted probability. Results Of 95 patients enrolled, 35 had TPE, 46 had malignant PE and 14 had PE due to other aetiologies. Interferon-γ (IFN-γ), adenosine deaminase (ADA), decoy receptor (DcR) 3, monocyte chemo-attractant protein (MCP)-1, IFN-induced protein (IP)-10, granzyme A and perforin were higher in TPE than in PE of other aetiologies. By logistic regression analysis, IFN-γ?75pg/mL, ADA ? 40 IU/mL, DcR3 ? 9.3 ng/mL and soluble tumour necrosis factor receptor 1 (TNF-sR1) ? 3.2 ng/mL were independent factors associated with TPE. The predicted probability based on the four predictors had an area under the ROC curve of 0.920, with 82.9% sensitivity and 86.7% specificity under the cut-off value of 0.303. In the TPE group, patients with positive PE/pleural culture for Mycobacterium tuberculosis had higher pleural IFN-γ, MCP-1, IP-10 and perforin than those with positive sputum but negative PE culture. Conclusions While pleural interferon-γ and ADA are conventional markers for diagnosing TPE, simultaneous measurements of DcR3 and TNF-sR1 can improve the diagnostic efficacy. Early diagnosis of tuberculous pleural effusion remains difficult. Measuring pleural interferon-γ, adenosine deaminase, decoy receptor 3 and soluble tumour necrosis factor receptor-1 together can improve the low sensitivity of assaying either interferon-γ or adenosine deaminase alone, and may avoid pleural biopsy which is in some patients a high-risk procedure. ? 2014 Asian Pacific Society of Respirology. | en_US |
dc.relation.ispartof | Respirology | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adenosine deaminase; antiinflammatory cytokine; cytokine; decoy receptor 3; gamma interferon; gamma interferon inducible protein 10; granzyme A; inflammatory cytokine; monocyte chemotactic protein 1; perforin; unclassified drug; adenosine deaminase; biological marker; decoy receptor 3; gamma interferon; perforin; tumor necrosis factor receptor 1; adult; aged; Article; bacterium culture; cytotoxic T lymphocyte; diagnostic test accuracy study; effector cell; female; human; human cell; lung cancer; lymphocyte; major clinical study; male; Mycobacterium tuberculosis; pleura effusion; prospective study; receiver operating characteristic; sensitivity and specificity; sputum; tuberculosis; tuberculous pleural effusion; blood; complication; cytotoxic T lymphocyte; inflammation; isolation and purification; metabolism; middle aged; Mycobacterium tuberculosis; pathogenicity; pathology; pathophysiology; Pleural Effusion; Tuberculosis, Pleural; Adenosine Deaminase; Aged; Biomarkers; Female; Humans; Inflammation; Interferon-gamma; Male; Middle Aged; Mycobacterium tuberculosis; Perforin; Pleural Effusion; Receptors, Tumor Necrosis Factor, Member 6b; Receptors, Tumor Necrosis Factor, Type I; ROC Curve; Sensitivity and Specificity; T-Lymphocytes, Cytotoxic; Tuberculosis, Pleural | - |
dc.title | Diagnostic role of inflammatory and anti-inflammatory cytokines and effector molecules of cytotoxic T lymphocytes in tuberculous pleural effusion | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/resp.12414 | - |
dc.identifier.pmid | 25355638 | - |
dc.identifier.scopus | 2-s2.0-84918502782 | - |
dc.relation.pages | 147-154 | en_US |
dc.relation.journalvolume | 20 | en_US |
dc.relation.journalissue | 1 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | National Taiwan University Hospital Hsin-Chu Branch | - |
crisitem.author.dept | NTU BioMedical Park Hospital | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.orcid | 0000-0003-0311-5148 | - |
crisitem.author.orcid | 0000-0003-3406-366X | - |
crisitem.author.orcid | 0000-0001-5785-0733 | - |
crisitem.author.orcid | 0000-0003-2772-8037 | - |
crisitem.author.orcid | 0000-0002-0605-5040 | - |
crisitem.author.orcid | 0000-0001-5664-9392 | - |
crisitem.author.orcid | 0000-0002-7654-2450 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Hsin-Chu Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學檢驗暨生物技術學系 |
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