https://scholars.lib.ntu.edu.tw/handle/123456789/510020
DC Field | Value | Language |
---|---|---|
dc.contributor.author | UN-IN WU | en_US |
dc.contributor.author | JANN-TAY WANG | en_US |
dc.contributor.author | WANG-HUEI SHENG | en_US |
dc.contributor.author | HSIN-YUN SUN | en_US |
dc.contributor.author | ARISTINE CHENG | en_US |
dc.contributor.author | Hsu, L. Y. | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.contributor.author | YEE-CHUN CHEN | en_US |
dc.date.accessioned | 2020-07-14T08:57:18Z | - |
dc.date.available | 2020-07-14T08:57:18Z | - |
dc.date.issued | 2020-01-01 | - |
dc.identifier.issn | 1198743X | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/510020 | - |
dc.description.abstract | © 2020 Objectives: Early diagnosis of adult-onset immunodeficiency associated with neutralizing anti-interferon-gamma autoantibodies (anti-IFNγ Abs) remains difficult given the lack of a distinctive phenotype and a routine test. This study aimed to investigate the determinants of incorrect tentative diagnoses and useful clues for early disease recognition. Methods: This study enrolled adult patients who had unexplained opportunistic infections diagnosed at six hospitals and identified those having neutralizing anti-IFNγ Abs (cases). Demographics, medical history, initial presentations and laboratory data, causative pathogens, tentative diagnoses, and treatment were analysed and compared among individuals having neutralizing anti-IFNγ Abs (cases) and those without (controls). Results: Among the 154 patients enrolled, neutralizing anti-IFN-γ Abs were detected in 50 (71%) of 70 patients with disseminated non-tuberculous mycobacterial infection (dNTM) but not in 84 patients without dNTM. The median time from disease onset to the recognition of dNTM associated with neutralizing anti-IFNγ Abs was 1.6 years (range, 0.25–19 years). Incorrect tentative diagnoses resulted in the administration of anti-tuberculosis regimens (60%, 30/50), immunosuppressants (48%, 24/50), and systemic chemotherapy (2%, 10/50) to the 50 cases. Multivariate analysis revealed that case patients were more likely than controls to present with multiple bone lesions (adjusted odds ratio (OR), 27.16; 95% confidence interval (CI), 1.21–609.59) and leukocytosis (adjusted OR, 1.48; 95% CI, 1.12–1.95); however, the controls had a higher rate of mycobacterial bloodstream infection (adjusted OR, 0.05; 95% CI 0.00–0.66). Conclusions: The high rate of incorrect tentative diagnoses led to frequent inappropriate management in patients with neutralizing anti-IFNγ Abs, and highlighted the need for increased awareness among clinicians. | en_US |
dc.relation.ispartof | Clinical Microbiology and Infection | en_US |
dc.subject | Adult-onset immunodeficiency | Disseminated non-tuberculous mycobacterial infections | Incorrect diagnoses | metastatic carcinoma | Neutralizing anti-interferon-gamma-autoantibodies | TB | en_US |
dc.subject | Adult-onset immunodeficiency; Disseminated non-tuberculous mycobacterial infections; Incorrect diagnoses; metastatic carcinoma; Neutralizing anti-interferon-gamma-autoantibodies; TB | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | autoantibody; gamma interferon antibody; immunosuppressive agent; neutralizing antibody; tuberculostatic agent; autoantibody; gamma interferon; neutralizing antibody; adult; aged; antibody detection; Article; atypical mycobacteriosis; bloodstream infection; bone lesion; chemotherapy; clinical feature; comparative study; connective tissue disease; controlled study; data analysis software; demography; diagnostic error; disseminated non tuberculous mycobacterial infection; early diagnosis; enzyme linked immunosorbent assay; female; fever; human; idiopathic disease; immunoglobulin G4 related disease; leukemia; leukocytosis; lymphadenopathy; lymphoma; major clinical study; male; metastasis; multicenter study; multiple fracture; opportunistic infection; priority journal; prospective study; rheumatoid arthritis; skin defect; systemic lupus erythematosus; systemic therapy; Taiwan; tuberculosis; wasting syndrome; blood; diagnostic error; immune deficiency; immunology; middle aged; very elderly; Adult; Aged; Aged, 80 and over; Antibodies, Neutralizing; Autoantibodies; Diagnostic Errors; Female; Humans; Immunologic Deficiency Syndromes; Interferon-gamma; Male; Middle Aged; Mycobacterium Infections, Nontuberculous; Opportunistic Infections; Prospective Studies | - |
dc.title | Incorrect diagnoses in patients with neutralizing anti-interferon-gamma-autoantibodies | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.cmi.2020.02.030 | - |
dc.identifier.pmid | 32120037 | - |
dc.identifier.scopus | 2-s2.0-85083019660 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85083019660 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Center for Infection Control | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Education-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Center for Infection Control | - |
crisitem.author.orcid | 0000-0001-8182-6071 | - |
crisitem.author.orcid | 0000-0002-0924-3469 | - |
crisitem.author.orcid | 0000-0002-5605-7853 | - |
crisitem.author.orcid | 0000-0003-0074-7721 | - |
crisitem.author.orcid | 0000-0002-1182-7375 | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.orcid | 0000-0002-1816-9010 | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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