https://scholars.lib.ntu.edu.tw/handle/123456789/510202
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yeh J.-H. | en_US |
dc.contributor.author | CHUN-TA HUANG | en_US |
dc.contributor.author | Liu C.-H. | en_US |
dc.contributor.author | SHENG-YUAN RUAN | en_US |
dc.contributor.author | Tsai Y.-J. | en_US |
dc.contributor.author | YING-CHUN CHIEN | en_US |
dc.contributor.author | CHING-YAO YANG | en_US |
dc.contributor.author | CHUN-KAI HUANG | en_US |
dc.contributor.author | CHIA-LIN HSU | en_US |
dc.contributor.author | LU-CHENG KUO | en_US |
dc.contributor.author | PEI-LIN LEE | en_US |
dc.contributor.author | SHIH-CHI KU | en_US |
dc.contributor.author | PING-HUNG KUO | en_US |
dc.contributor.author | CHONG-JEN YU | en_US |
dc.contributor.author | HINT Study Group | en_US |
dc.creator | Yeh J.-H.;Huang C.-T.;Liu C.-H.;Ruan S.-Y.;Tsai Y.-J.;Chien Y.-C.;Yang C.-Y.;Huang C.-K.;Hsu C.-L.;Kuo L.-C.;Pei-Lin Lee;Ku S.-C.;Kuo P.-H.;Yu C.-J.;Hint Study Group | - |
dc.date.accessioned | 2020-07-20T05:28:06Z | - |
dc.date.available | 2020-07-20T05:28:06Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84918836040&doi=10.1371%2fjournal.pone.0115301&partnerID=40&md5=dff45bd75e5f6f094f0a2a257e0239a2 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/510202 | - |
dc.description.abstract | Background and Objective: Several studies on diagnostic accuracy of pleural N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) for effusions from congestive heart failure (CHF) conclude that pleural NT-pro-BNP is a useful biomarker with high diagnostic accuracy for distinguishing CHF effusions. However, its applicability in critical care settings remains uncertain and requires further investigations. Methods: NT-proBNP was measured in pleural fluid samples of a prospective cohort of intensive care unit patients with pleural effusions. Receiver operating characteristic curve analysis was performed to determine diagnostic accuracy of pleural NT-pro-BNP for prediction of CHF effusions. Results: One hundred forty-seven critically ill patients were evaluated, 38 (26%) with CHF effusions and 109 (74%) with non-CHF effusions of various causes. Pleural NT-proBNP levels were significantly elevated in patients with CHF effusions. Pleural NT-pro-BNP demonstrated the area under the curve of 0.87 for diagnosing effusions due to CHF. With a cutoff of 2200 pg/mL, pleural NT-proBNP displayed high sensitivity (89%) but moderate specificity (73%). Notably, 29 (27%) of 109 patients with non-CHF effusions had pleural NT-proBNP levels >2200 pg/ mL and these patients were more likely to experience septic shock (18/29 vs. 10/ 80, P<0.001) or acute kidney injury (19/29 vs. 9/80, P<0.001). Conclusions: Among critically ill patients, pleural NT-proBNP measurements remain a useful diagnostic aid in evaluation of pleural effusions. However, patients with non-CHF effusions may exhibit high pleural NT-proBNP concentrations if they suffer from septic shock or acute kidney injury. Accordingly, it is suggested that clinical context should be taken into account when interpreting pleural NT-proBNP values in critical care settings. ? 2014 Yeh et al. | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.ispartof | PLoS ONE | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amino terminal pro brain natriuretic peptide; biological marker; brain natriuretic peptide; peptide fragment; pro-brain natriuretic peptide (1-76); acute kidney failure; adult; aged; Article; cohort analysis; congestive heart failure; controlled study; critically ill patient; diagnostic accuracy; female; high risk population; human; intensive care unit; major clinical study; male; pleura effusion; pleura fluid; prediction; prospective study; protein analysis; receiver operating characteristic; reference value; sensitivity and specificity; septic shock; thoracocentesis; critical illness; heart failure; metabolism; pathology; Pleural Effusion; Taiwan; very elderly; Aged; Aged, 80 and over; Biomarkers; Cohort Studies; Critical Illness; Female; Heart Failure; Humans; Male; Natriuretic Peptide, Brain; Peptide Fragments; Pleural Effusion; Prospective Studies; Taiwan | - |
dc.title | Cautious application of pleural N-terminal pro-B-type natriuretic peptide in diagnosis of congestive heart failure pleural effusions among critically ill patients | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1371/journal.pone.0115301 | - |
dc.identifier.pmid | 25502236 | - |
dc.identifier.scopus | 2-s2.0-84918836040 | - |
dc.relation.pages | e115301 | en_US |
dc.relation.journalvolume | 9 | en_US |
dc.relation.journalissue | 12 | en_US |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Center of Sleep Disorder | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | National Taiwan University Hospital Hsin-Chu Branch | - |
crisitem.author.dept | NTU BioMedical Park Hospital | - |
crisitem.author.orcid | 0000-0002-5234-4986 | - |
crisitem.author.orcid | 0000-0002-7949-7253 | - |
crisitem.author.orcid | 0000-0003-0184-323X | - |
crisitem.author.orcid | 0000-0003-4927-4814 | - |
crisitem.author.orcid | 0000-0001-7392-6363 | - |
crisitem.author.orcid | 0000-0001-5785-0733 | - |
crisitem.author.orcid | 0000-0003-4247-5197 | - |
crisitem.author.orcid | 0000-0002-6883-9502 | - |
crisitem.author.orcid | 0000-0002-4123-0967 | - |
crisitem.author.orcid | 0000-0003-3756-3395 | - |
crisitem.author.orcid | 0000-0001-5664-9392 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Hsin-Chu Branch | - |
顯示於: | 醫學系 |
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