https://scholars.lib.ntu.edu.tw/handle/123456789/510307
標題: | Using a three-chamber culture chip to study the interactions among cancer cells and two types of stromal cells | 作者: | Lee C.-H. Hsu T.-H. Kao Y.-L. Lin W.-L. WEI-YU LIAO |
關鍵字: | Myofibroblast; Pneumatic microvalve; Tumor associate macrophage; Tumor necrosis factor | 公開日期: | 2011 | 卷: | 1 | 起(迄)頁: | 167-169 | 來源出版物: | 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 | 摘要: | We employ a microfluidic cell culture chip with three culture chambers to investigate the interactions among cancer cells, macrophages and myofibroblasts. The channels connecting the chambers are controlled by pneumatic microvalves. We revealed that the conditioned media of macrophages and myofibroblasts have synergistic effects on accelerating the migration of cancer cells. However, as the myofibroblasts are pretreated with the conditioned medium of macrophages, the myofibroblasts' ability to enhance the migration of cancer cells is suppressed. We confirmed that the tumor necrosis factor-α produced by macrophages degrades the activities of myofibroblasts. Copyright ? (2011) by the Chemical and Biological Microsystems Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84883766160&partnerID=40&md5=95d52059aaa0ac72e04174cc66d3bd0d https://scholars.lib.ntu.edu.tw/handle/123456789/510307 |
ISSN: | #VALUE! | SDG/關鍵字: | Conditioned medias; Conditioned medium; Culture chambers; Micro valves; Microfluidic cell culture; Myofibroblasts; Synergistic effect; Tumor necrosis factors; Cell culture; Fibroblasts; Glycoproteins; Pneumatics; Valves (mechanical); Macrophages |
顯示於: | 醫學系 |
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