https://scholars.lib.ntu.edu.tw/handle/123456789/510312
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHAO-CHI HO | en_US |
dc.contributor.author | WEI-YU LIAO | en_US |
dc.contributor.author | Wang C.-Y. | en_US |
dc.contributor.author | Lu Y.-H. | en_US |
dc.contributor.author | Huang H.-Y. | en_US |
dc.contributor.author | Chen H.-Y. | en_US |
dc.contributor.author | Chan W.-K. | en_US |
dc.contributor.author | HUEI-WEN CHEN | en_US |
dc.contributor.author | PAN-CHYR YANG | en_US |
dc.date.accessioned | 2020-07-21T06:09:17Z | - |
dc.date.available | 2020-07-21T06:09:17Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1073-449X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-41749104887&doi=10.1164%2frccm.200704-641OC&partnerID=40&md5=0dbe9e85b687fd4bca7c16df67253544 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/510312 | - |
dc.description.abstract | Rationale: Triggering receptor expressed on myeloid cells (TREM)-1 is a molecule crucial for the triggering and amplification of inflammatory response and a new biomarker for sepsis. Tumor-associated macrophages and inflammation in the tumor microenvironment are also involved in cancer progression. Objectives: To determine the role of TREM-1 in tumor-associated macrophage and cancer progression. Methods: Using ELISA and Western blot, we measured soluble TREM-1 levels in 65 pleural effusions of various etiologies. We evaluated TREM-1-positive cells by immunocytochemistry in malignant pleural effusion and in lung tumor versus adjacent normal tissue in surgical specimens from 68 patients with non-small cell lung cancer (NSCLC). TREM-1 expression was correlated with patient survival. TREM-1 expression in primary isolated peripheral blood macrophages cocultured with lung cancer cell lines was determined by quantitative real-time reverse transcriptase-polymerase chain reaction. Measurements and Main Results: Soluble TREM-1 and tumor-associated macrophage TREM-1 expression was increased in malignant pleural effusions in patients with NSCLC. Lung cancer cells could directly up-regulate TREM-1 and proinflammatory cytokine (tumor necrosis factor-α, IL-1β) expression in primary isolated peripheral blood macrophages in coculture experiments. Increased TREM-1-positive tumor-associated macrophages in tumor tissue of patients with NSCLC were associated with reduced disease-free (P = 0.011) and overall survival (P = 0.004). Multivariate Cox regression analysis indicated that TREM-1 was an independent predictor of patient survival (hazard ratio, 2.72; 95% confidence interval, 1.33-5.57; P = 0.006). Conclusions: Cancer cells can directly up-regulate TREM-1 expression in patients' macrophages. TREM-1 expression in tumor-associated macrophages is associated with cancer recurrence and poor survival of patients with NSCLC. TREM-1 and the inflammatory response may play an important role in cancer progression. | - |
dc.relation.ispartof | American Journal of Respiratory and Critical Care Medicine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | interleukin 1beta; triggering receptor expressed on myeloid cells 1; tumor necrosis factor alpha; immunoglobulin receptor; membrane protein; TREM1 protein, human; unclassified drug; adult; aged; article; cancer cell culture; cancer growth; cancer survival; cell culture; controlled study; enzyme linked immunosorbent assay; female; human; human cell; human tissue; lung non small cell cancer; major clinical study; male; outcome assessment; pleura effusion; priority journal; protein expression; reverse transcription polymerase chain reaction; tumor associated leukocyte; Western blotting; disease course; immunology; inflammation; Kaplan Meier method; lung tumor; macrophage; metabolism; middle aged; multivariate analysis; pathology; prognosis; proportional hazards model; prospective study; upregulation; Carcinoma, Non-Small-Cell Lung; Disease Progression; Female; Humans; Inflammation; Kaplan-Meiers Estimate; Lung Neoplasms; Macrophages; Male; Membrane Glycoproteins; Middle Aged; Multivariate Analysis; Pleural Effusion; Prognosis; Proportional Hazards Models; Prospective Studies; Receptors, Immunologic; Up-Regulation | - |
dc.title | TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1164/rccm.200704-641OC | - |
dc.identifier.pmid | 18096709 | - |
dc.identifier.scopus | 2-s2.0-41749104887 | - |
dc.relation.pages | 763-770 | - |
dc.relation.journalvolume | 177 | - |
dc.relation.journalissue | 7 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Toxicology | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-8156-2413 | - |
crisitem.author.orcid | 0000-0001-6383-3470 | - |
crisitem.author.orcid | 0000-0001-5051-9896 | - |
crisitem.author.orcid | 0000-0001-6330-6048 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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