https://scholars.lib.ntu.edu.tw/handle/123456789/510434
標題: | Soluble triggering receptor expressed on myeloid cells-1 as an infection marker for patients with neutropenic fever | 作者: | Lin C.-H. MING YAO SZU-CHUN HSU CHAO-CHI HO Lin M.-T. Lin C.-A. Hu F.-C. CHONG-JEN YU HWEI-FANG TIEN |
公開日期: | 2011 | 出版社: | Lippincott Williams and Wilkins | 卷: | 39 | 期: | 5 | 起(迄)頁: | 993-999 | 來源出版物: | Critical Care Medicine | 摘要: | OBJECTIVE: To assess the value of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of infection in patients with neutropenic fever comparing with procalcitonin and C-reactive protein. DESIGN: Prospective, comparative, single-center study. SETTING: Hematology ward at a university hospital. SUBJECTS: Seventy-five patients with neutropenic fever after chemotherapy for their hematologic malignancies. INTERVENTION: None. MEASUREMENTS AND MAIN RESULTS: A total of 137 episodes of neutropenic fever in 75 patients were classified into 75 episodes of documented infections and 62 low likelihood of infection. The level of soluble triggering receptor expressed on myeloid cells-1 was significantly elevated in the group of documented infection. The area under the receiver operating characteristic curve for the diagnosis of infection was 0.719 (95% confidence interval, 0.632-0.806; p <.0001) for soluble triggering receptor expressed on myeloid cells-1, which was larger than the values of 0.501 for procalcitonin (0.465-0.657; p =.218) and 0.491 for C-reactive protein (0.394-0.589, p =.858). The fitted marginal logistic regression model of all episodes contained two statistically significant predictors of infection: soluble triggering receptor expressed on myeloid cells-1 (per 1-pg/mL increase; odds ratio [OR], 1.0002; 95% CI, 1.0001-1.0003; p <.0001) and procalcitonin (per 1-ng/mL increase; OR, 1.0094; 95% CI, 1.0005-1.0184; p =.0002). In a diagnostic panel with soluble triggering receptor expressed on myeloid cells-1 and procalcitonin, the sensitivity and specificity were 88% and 48%, respectively. CONCLUSIONS: Soluble triggering receptor expressed on myeloid cells-1 is better than procalcitonin in the prediction of infection at the onset of neutropenic fever. By applying soluble triggering receptor expressed on myeloid cells-1 and procalcitonin together, low or high risk for infection can be defined at the onset of neutropenic fever. Copyright ? 2011 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79955481145&doi=10.1097%2fCCM.0b013e31820a92dc&partnerID=40&md5=3e60d4ad20c372448de96ec37656a4a1 https://scholars.lib.ntu.edu.tw/handle/123456789/510434 |
ISSN: | 0090-3493 | DOI: | 10.1097/CCM.0b013e31820a92dc | SDG/關鍵字: | C reactive protein; procalcitonin; rituximab; triggering receptor expressed on myeloid cells 1; adult; aged; bone marrow cell; chemotherapy; comparative study; conference paper; disease marker; febrile neutropenia; female; human; infection; infection risk; major clinical study; male; priority journal; prospective study; receiver operating characteristic; sensitivity and specificity |
顯示於: | 醫學系 |
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