https://scholars.lib.ntu.edu.tw/handle/123456789/510926
標題: | The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults | 作者: | Lin C.-Y. Wen L.-L. LIAN-YU LIN Wen T.-W. Lien G.-W. SANDY HUEY-JEN HSU KUO-LIONG CHIEN Liao C.-C. Sung F.-C. PAU-CHUNG CHEN TA-CHEN SU |
公開日期: | 2013 | 卷: | 244-245 | 起(迄)頁: | 637-644 | 來源出版物: | Journal of Hazardous Materials | 摘要: | Perfluorinated chemicals (PFCs) have been widely used in a variety of products worldwide for years. However, the effect of PFCs on thyroid function has not yet been clearly defined. We recruited 567 subjects (aged 12-30 years) in a population-based cohort of adolescents and young adults with abnormal urinalysis in the childhood to determine the relationship between serum level of PFCs and the levels of serum free thyroxine (T4) and thyroid stimulating hormone (TSH). The geometric means and geometric standard deviation concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) were 2.67 (2.96). ng/ml, 7.78 (2.42). ng/ml, 1.01 (3.48). ng/ml and 5.81 (2.92). ng/ml, respectively. Differences in the levels of free T4 and TSH across different categories of PFOA, PFOS and PFUA were insignificant. After controlling for confounding factors, multiple linear regression analyses revealed mean serum level of free T4 increased significantly across categories (<60th, 60-89 and >90th percentiles) of PFNA (P for trend =0.012 in the full model). The association between PFNA and free T4 was more significant in male subjects in age group 20-30, active smokers and in those with higher body mass index in stratified analysis. Serum concentrations of PFNA were associated with serum free T4 levels in adolescents and young adults. ? 2012 Elsevier B.V. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/510926 | ISSN: | 0304-3894 | DOI: | 10.1016/j.jhazmat.2012.10.049 | SDG/關鍵字: | Humans; PFC; PFNA; Thyroid; Thyroxine; Linear regression; Body fluids; perfluorononanoic acid; perfluorooctanesulfonic acid; perfluorooctanoic acid; thyrotropin; thyroxine; abnormality; adolescence; adult; age class; bioaccumulation; body mass; cohort analysis; health impact; hormone; multiple regression; organofluorine; public health; serum; smoking; young population; adolescent; adult; article; body mass; child; cohort analysis; concentration (parameters); female; human; male; school child; smoking; thyroid function; thyrotropin blood level; thyroxine blood level; Adolescent; Adult; Alkanesulfonic Acids; Child; Cohort Studies; Environmental Monitoring; Environmental Pollutants; Female; Fluorocarbons; Humans; Male; Taiwan; Thyroid Gland; Thyrotropin; Thyroxine; Young Adult |
顯示於: | 醫學檢驗暨生物技術學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。