https://scholars.lib.ntu.edu.tw/handle/123456789/510927
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin C.-Y. | en_US |
dc.contributor.author | Wen L.-L. | en_US |
dc.contributor.author | LIAN-YU LIN | en_US |
dc.contributor.author | Wen T.-W. | en_US |
dc.contributor.author | Lien G.-W. | en_US |
dc.contributor.author | CHIA-YANG CHEN | en_US |
dc.contributor.author | SANDY HUEY-JEN HSU | en_US |
dc.contributor.author | KUO-LIONG CHIEN | en_US |
dc.contributor.author | Sung F.-C. | en_US |
dc.contributor.author | PAU-CHUNG CHEN | en_US |
dc.contributor.author | TA-CHEN SU | en_US |
dc.creator | Lin C.-Y.;Wen L.-L.;Lin L.-Y.;Wen T.-W.;Lien G.-W.;Chen C.-Y.;Sandy Huey-Jen Hsu;Chien K.-L.;Sung F.-C.;Chen P.-C.;Su T.-C. | - |
dc.date.accessioned | 2020-08-05T00:38:51Z | - |
dc.date.available | 2020-08-05T00:38:51Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0013-936X | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/510927 | - |
dc.description.abstract | In animals, perfluorinated chemicals (PFCs), specifically perfluorooctanoic acid (PFOA) and perfluorooctane sulfate (PFOS), function as peroxisome proliferator-activated receptor (PPAR) alpha agonists. However, the relevance of animal (primarily rodent) data to humans is unresolved. While plasma adiponectin level is very responsive to PPAR gamma agonist drugs, it has not been determined whether adiponectin level is related to serum PFCs concentrations. In the present study, 287 subjects (12-30 years of age) were recruited to determine the relationship between serum level of PFCs and serum level of adiponectin. The results showed males had higher serum PFOS concentrations than females and that those with metabolic syndrome had lower serum PFOA than controls. Besides, it showed regional elevations of the perfluoroundecanoic acid (PFUA) (median concentration: 7.11 ng/mL) in the study subjects. No relationship of PFOA, PFOS, PFUA, and the sum of all four PFCs was found to glucose homeostasis, adiponectin level, lipid profile, and inflammatory markers. The median and the range of perfluorononanoic acid (PFNA) concentration (in ng/mL; for four categories corresponding to the <50, 50-74, 75-89, and ?90th percentiles) were 0.38 (0.38-1.68), 3.22 (1.73-4.65), 5.85 (4.75-8.29), 10.56 (8.40-25.40), respectively. After controlling for confounding factors, multiple linear regression analysis revealed that the mean natural log-transformed level of adiponectin increased significantly across categories of PFNA (in ng/mL; 8.78, 8.73, 9.06, 9.36; P for trend = 0.010 in the full model). In conclusion, higher serum PFNA concentration is associated with elevated serum adiponectin concentration. ? 2011 American Chemical Society. | - |
dc.relation.ispartof | Environmental Science and Technology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Adiponectin; Full model; Glucose homeostasis; Lipid profile; Median concentration; Metabolic syndromes; Multiple linear regression analysis; Perfluorinated chemicals; Perfluorononanoic acids; Perfluorooctanoic acid; Peroxisome proliferator-activated receptor; Serum adiponectin; Serum levels; Animals; Concentration (process); Cytology; Glucose; Linear regression; Body fluids; adiponectin; perfluoro compound; perfluorononanoic acid; perfluorooctane sulfate; perfluorooctanoic acid; perfluoroundecanoic acid; unclassified drug; biochemistry; cohort analysis; concentration (composition); drug; homeostasis; hypertension; multiple regression; peptide; public health; rodent; serum; sex-related difference; young population; adolescent; adult; article; blood level; child; controlled study; female; glucose homeostasis; human; hypertension; major clinical study; male; metabolic syndrome X; multiple linear regression analysis; school child; sex difference; Taiwan; Adiponectin; Adolescent; Adult; Child; Cohort Studies; Environmental Exposure; Environmental Pollutants; Female; Fluorocarbons; Humans; Hypertension; Male; Taiwan; Young Adult; Taiwan | - |
dc.title | Associations between levels of serum perfluorinated chemicals and adiponectin in a young hypertension cohort in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1021/es201964x | - |
dc.identifier.pmid | 22047537 | - |
dc.identifier.scopus | 2-s2.0-83455170712 | - |
dc.relation.pages | 10691-10698 | - |
dc.relation.journalvolume | 45 | - |
dc.relation.journalissue | 24 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Master's Program in Smart Medicine and Health Informatics (SMARTMHI) | - |
crisitem.author.dept | Institute of Food Safety and Health | - |
crisitem.author.dept | Institute of Environmental and Occupational Health Sciences | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Institute of Environmental and Occupational Health Sciences | - |
crisitem.author.dept | Environmental and Occupational Medicine-NTUH | - |
crisitem.author.dept | Environmental and Occupational Medicine | - |
crisitem.author.dept | Environmental and Occupational Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-7505-6429 | - |
crisitem.author.orcid | 0000-0001-5301-1609 | - |
crisitem.author.orcid | 0000-0002-5539-4858 | - |
crisitem.author.orcid | 0000-0003-4979-8351 | - |
crisitem.author.orcid | 0000-0002-6242-5974 | - |
crisitem.author.orcid | 0000-0001-7523-7166 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | International College | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學檢驗暨生物技術學系 |
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