https://scholars.lib.ntu.edu.tw/handle/123456789/511174
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JANE WANG | en_US |
dc.contributor.author | Wang M.-Y. | en_US |
dc.contributor.author | WEN-HUNG KUO | en_US |
dc.contributor.author | Chen K.-L. | en_US |
dc.contributor.author | TIFFANY TING-FANG SHIH | en_US |
dc.date.accessioned | 2020-08-06T07:51:46Z | - |
dc.date.available | 2020-08-06T07:51:46Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0730-725X | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/511174 | - |
dc.description.abstract | Purpose: To investigate the water and lipid composition of normal women breasts on proton MR spectroscopy (1H-MRS), and the association of breast cancer risk factors with 1H-MRS parameters. Materials and methods: Three groups of participants were included: group 1, women without a family history of breast cancer (n = 49); group 2, women with at least one affected first-degree relative (n = 77); group 3, contralateral normal breasts of women with newly diagnosed unilateral breast cancer (n = 84). 1H-MRS parameters were shown below: water fraction 1 (WF1) = (water integral)/(water integral + integral for methylene peak); lipid line width for methylene resonance (LW1) and lipid line width for methyl peaks (LW2) were measured. The association of breast cancer risk factors - age, breast density, body mass index (BMI), menopausal status, group with 1H-MRS parameters - was analyzed by multiple linear regression. Results: In age-adjusted multiple linear regression, breast density was positively associated with WF1 (P = 0.009, 0.001, and < 0.001 for groups 1, 2, and 3, respectively). BMI was inversely associated with LW1 in groups 1 (P = 0.040) and 3 (P = 0.005). In group 3, premenopausal breasts had lower LW2 than their postmenopausal counterparts (P = 0.033). Group 3 had narrower LW2 than group 2 (P = 0.007). Conclusions: The risk factors for breast cancer were associated with 1H-MRS parameters. ? 2015 Elsevier Inc. | - |
dc.relation.ispartof | Magnetic Resonance Imaging | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adult; age; Article; body mass; breast cancer; breast density; cancer risk; controlled study; family history; female; first degree relative; human; lipid composition; major clinical study; nuclear magnetic resonance scanner; postmenopause; premenopause; priority journal; prospective study; proton nuclear magnetic resonance; water content; adipose tissue; aged; breast; breast tumor; chemistry; diagnostic imaging; middle aged; risk factor; statistical model; lipid; water; Adipose Tissue; Adult; Aged; Breast; Breast Density; Breast Neoplasms; Female; Humans; Linear Models; Lipids; Middle Aged; Proton Magnetic Resonance Spectroscopy; Risk Factors; Water | - |
dc.title | Proton MR spectroscopy of normal breasts: Association of risk factors for breast cancer with water and lipid composition of the breast | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.mri.2015.12.028 | - |
dc.identifier.pmid | 26712654 | - |
dc.identifier.scopus | 2-s2.0-84960924952 | - |
dc.relation.pages | 524-528 | - |
dc.relation.journalvolume | 34 | - |
dc.relation.journalissue | 4 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.orcid | 0000-0001-7239-6313 | - |
crisitem.author.orcid | 0000-0002-9881-4605 | - |
crisitem.author.orcid | 0000-0002-3292-9688 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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