https://scholars.lib.ntu.edu.tw/handle/123456789/511217
標題: | Detecting small lung tumors in mouse models by refractive-index microradiology | 作者: | Chien C.-C. Zhang G. Hwu Y. Liu P. Yue W. Sun J. Li Y. Xue H. Xu L.X. Wang C.H. Chen N. Lu C.H. Lee T.-K. Yang Y.-C. Lu Y.-T. Ching Y.-T. TIFFANY TING-FANG SHIH PAN-CHYR YANG Je J.H. Margaritondo G. |
公開日期: | 2011 | 卷: | 401 | 期: | 3 | 起(迄)頁: | 827-835 | 來源出版物: | Analytical and Bioanalytical Chemistry | 摘要: | Refractive-index (phase-contrast) radiology was able to detect lung tumors less than 1 mm in live mice. Significant micromorphology differences were observed in the microradiographs between normal, inflamed, and lung cancer tissues. This was made possible by the high phase contrast and by the fast image taking that reduces the motion blur. The detection of cancer and inflammation areas by phase contrast microradiology and microtomography was validated by bioluminescence and histopathological analysis. The smallest tumor detected is less than 1 mm 3 with accuracy better than 1?×?10 -3 mm 3. This level of performance is currently suitable for animal studies, while further developments are required for clinical application. [Figure not available: see fulltext.] ? 2011 Springer-Verlag. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/511217 | ISSN: | 1618-2642 | DOI: | 10.1007/s00216-011-5117-x | SDG/關鍵字: | Animal studies; Clinical application; Further development; Histopathological analysis; Lung Cancer; Lung tumor; Micro-tomography; Micromorphologies; Microradiology; Motion blur; Mouse models; Phase contrasts; Phase-contrast; Realtime imaging; Synchrotron X-ray imaging; Diseases; Mammals; Radiology; Tumors; Biological organs; collagen; animal; article; brain tumor; chemistry; disease model; glioma; infrared spectroscopy; lung tumor; male; mouse; pathology; radiography; rat; standard; tumor cell line; Animals; Brain Neoplasms; Cell Line, Tumor; Collagen; Disease Models, Animal; Glioma; Lung Neoplasms; Male; Mice; Rats; Reference Standards; Spectroscopy, Fourier Transform Infrared; Animalia; Mus |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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