https://scholars.lib.ntu.edu.tw/handle/123456789/512311
標題: | Hemoglobin Levels and Weaning Outcome of Mechanical Ventilation in Difficult-To-Wean Patients: A Retrospective Cohort Study | 作者: | Lai Y.-C. SHENG-YUAN RUAN CHUN-TA HUANG PING-HUNG KUO CHONG-JEN YU |
公開日期: | 2013 | 卷: | 8 | 期: | 8 | 起(迄)頁: | e73743 | 來源出版物: | PLoS ONE | 摘要: | Introduction:The effect of hemoglobin levels on the weaning outcomes of mechanically ventilated patients remains under debate, particularly for the patients with difficult weaning. This study aims to evaluate the effect of hemoglobin levels on weaning outcomes in difficult-to-wean patients.Methods:This retrospective cohort study was conducted in a university-affiliated teaching hospital in Taiwan. Patients who fulfilled the criteria of difficult weaning were enrolled. Medical records were reviewed to obtain data on hemograms, biochemistry tests, transfusion records, comorbidities and weaning outcome. The association between hemoglobin levels and 30-day weaning outcomes was evaluated using a logistic regression model.Results:A total of 751 patients received mechanical ventilation during the study period, 138 of whom fulfilled the criteria of difficult weaning. Compared with the patients whose hemoglobin was <8 g/dL, those with higher hemoglobin levels were more likely to be successfully weaned (odds ratio [OR], 3.69; 95% CI, 1.22-11.15 for hemoglobin 8-10 g/dL and OR, 4.16, 95% CI, 1.30-13.29 for hemoglobin >10 g/dL). Multivariate analysis showed that the odds ratio for weaning success remained significant for hemoglobin levels of 8-10 g/dL (adjusted OR, 3.3; 95% CI, 1.07-10.15) with borderline significance for hemoglobin level > 10 g/dL (adjusted OR, 2.95, 95% CI, 0.88-9.96).Conclusions:Hemoglobin level is independently associated with weaning outcome in difficult-to-wean patients. Further studies are needed to evaluate whether a restrictive transfusion trigger for acute critical illness is also appropriate for such patients. ? 2013 Lai et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84883337837&doi=10.1371%2fjournal.pone.0073743&partnerID=40&md5=f8721dba4188e36870b3f178af99c3f9 https://scholars.lib.ntu.edu.tw/handle/123456789/512311 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0073743 | SDG/關鍵字: | hemoglobin; aged; article; artificial ventilation; cohort analysis; controlled study; correlational study; critically ill patient; data analysis; disease classification; female; hemoglobin blood level; human; major clinical study; male; outcome assessment; prognosis; retrospective study; Taiwan; teaching hospital; weaning; Aged; Aged, 80 and over; Female; Follow-Up Studies; Hemoglobins; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Retrospective Studies; Time Factors; Ventilator Weaning |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。