https://scholars.lib.ntu.edu.tw/handle/123456789/512426
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Pan S.-W. | en_US |
dc.contributor.author | CHIN-CHUNG SHU | en_US |
dc.contributor.author | Feng J.-Y. | en_US |
dc.contributor.author | JANN-YUAN WANG | en_US |
dc.contributor.author | Chan Y.-J. | en_US |
dc.contributor.author | CHONG-JEN YU | en_US |
dc.contributor.author | Su W.-J. | en_US |
dc.creator | Pan S.-W.;Shu C.-C.;Feng J.-Y.;Jann-Yuan Wang;Chan Y.-J.;Yu C.-J.;Su W.-J. | - |
dc.date.accessioned | 2020-08-13T05:24:05Z | - |
dc.date.available | 2020-08-13T05:24:05Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1058-4838 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031898478&doi=10.1093%2fcid%2fcix479&partnerID=40&md5=158b27738cc1c8a9c4743a98eea8354c | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/512426 | - |
dc.description.abstract | Background. Persistent growth of Mycobacterium avium complex (MAC) in the lungs indicates continuous infection in MAC lung disease (MAC-LD), but its clinical significance has not been investigated. We aimed to evaluate the predictors of persistent culture-positivity for MAC (MAC-PP) and its impact on radiographic deterioration in MAC-LD. Methods. Patients with MAC-LD at multiple medical centers from 2011 to 2016 were enrolled retrospectively. Microbiological persistence of MAC-LD was defined as MAC-PP exceeding 1 year, in contrast with the negative-conversion group. The outcome was radiographic progression, namely, increased number of involved lung areas or cavitary formation. Results. Among 126 patients with MAC-LD, 75 (60%) were in the MAC-PP group; these patients had a higher proportion of radiographic progression (54%) than patients in the negative-conversion group (odds ratio [OR], 3.318; 95% confidence interval, 1.146-9.612). Independent predictors of MAC-PP were low body mass index (BMI), radiographic nodular-bronchiectatic (NB) pattern, and increase in the highest grade of acid-fast bacilli smear (AFS). Patients with BMI <21 kg/m2, NB pattern, and positive AFS had an OR of 17.7 for MAC-PP, and those with ?2 of the factors had a 4.5-fold increased OR for MAC-PP relative to the comparison group. Other than MAC-PP, the highest AFS grade and no anti-MAC treatment were correlated with radiographic progression. Conclusion. Microbiological persistence in patients with MAC-LD is not uncommon and leads to an increased risk of radiographic progression. The predictors of MAC-PP are low BMI, NB pattern, and high AFS grade; if these risk factors are present, anti- MAC treatment should be seriously considered. ? The Author 2017. | - |
dc.publisher | Oxford University Press | - |
dc.relation.ispartof | Clinical Infectious Diseases | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | tuberculostatic agent; antiinfective agent; adult; antibiotic therapy; Article; atypical mycobacteriosis; bacterium culture; body mass; chronic obstructive lung disease; coughing; diabetes mellitus; dyspnea; female; follow up; hemoptysis; human; lung infection; major clinical study; male; malignant neoplasm; medical record review; Mycobacterium avium complex; nonhuman; priority journal; retrospective study; sputum culture; thorax radiography; Youden index; aged; atypical mycobacteriosis; bronchiectasis; chronic disease; diagnostic imaging; disease exacerbation; lung disease; microbiology; middle aged; risk factor; sputum; very elderly; Aged; Aged, 80 and over; Anti-Bacterial Agents; Body Mass Index; Bronchiectasis; Chronic Disease; Disease Progression; Female; Humans; Lung Diseases; Male; Middle Aged; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection; Radiography, Thoracic; Retrospective Studies; Risk Factors; Sputum | - |
dc.title | Microbiological persistence in patients with mycobacterium avium complex lung disease: The predictors and the impact on radiographic progression | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1093/cid/cix479 | - |
dc.identifier.pmid | 28541556 | - |
dc.identifier.scopus | 2-s2.0-85031898478 | - |
dc.relation.pages | 927-934 | - |
dc.relation.journalvolume | 65 | - |
dc.relation.journalissue | 6 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | National Taiwan University Hospital Hsin-Chu Branch | - |
crisitem.author.dept | NTU BioMedical Park Hospital | - |
crisitem.author.orcid | 0000-0003-0311-5148 | - |
crisitem.author.orcid | 0000-0003-3406-366X | - |
crisitem.author.orcid | 0000-0001-5664-9392 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Hsin-Chu Branch | - |
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