https://scholars.lib.ntu.edu.tw/handle/123456789/512463
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHIN-CHUNG SHU | en_US |
dc.contributor.author | VIN-CENT WU | en_US |
dc.contributor.author | FENG-JUNG YANG | en_US |
dc.contributor.author | CHIA-LIN HSU | en_US |
dc.contributor.author | SUNG-CHING PAN | en_US |
dc.contributor.author | JANN-YUAN WANG | en_US |
dc.contributor.author | JANN-TAY WANG | en_US |
dc.contributor.author | CHONG-JEN YU | en_US |
dc.contributor.author | LI-NA LEE | en_US |
dc.creator | Shu C.-C.;Wu V.-C.;Yang F.-J.;Hsu C.-L.;Pan S.-C.;Jann-Yuan Wang;Wang J.-T.;Yu C.-J.;Lee L.-N. | - |
dc.date.accessioned | 2020-08-13T05:24:15Z | - |
dc.date.available | 2020-08-13T05:24:15Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0163-4453 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887016600&doi=10.1016%2fj.jinf.2013.07.029&partnerID=40&md5=ac9d109caa98a5a1e6c6acf89204c619 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/512463 | - |
dc.description.abstract | Background: Interferon-gamma release assay (IGRA) is popular for detecting latent tuberculosis infection (LTBI), but its dynamic change is uncertain in high-risk groups such as dialysis patients. Methods: Patients undergoing dialysis were prospectively enrolled. The QuantiFERON-TB Gold In-Tube (QFT-GIT) was used to detect LTBI. After 6 and 12 months, QFT-GIT was repeated to monitor dynamic changes. Results: Only 204 of 391 enrolled patients completed the study. The initial QFT-GIT positive rate of 22.1% decreased to 19.6% after 6 months and to 14.2% after 12 months. The 6-month reversion rate was 45.9% while the conversion rate was 7.7%. Sub-population with new QFT-GIT positivity had 87.5% reversion rate, higher than the 20.8% of patients with persistent QFT-GIT positivity. The QFT-GIT response was independently associated with persistent QFT-GIT positivity. Using 0.93IU/ml of the initial QFT-GIT response as the threshold can detect 79% persistent positivity in 6-month follow-up. Prior TB had a borderline significance for predicting conversion. Conclusions: In the dialysis population, reversion and conversion occur frequently within six months. The QFT-GIT positive population is heterogeneous and sub-populations have different reversion rates. Higher QFT-GIT positivity threshold can identify patients with persistent QFT-GIT positivity to prioritize follow-up and LTBI therapy. ? 2013 The British Infection Association. | - |
dc.relation.ispartof | Journal of Infection | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adult; article; clinical trial; cohort analysis; diagnostic equipment; diagnostic value; female; follow up; hemodialysis patient; human; interferon gamma release assay; latent tuberculosis; major clinical study; male; observational study; outcome assessment; prospective study; Conversion; Dialysis; Interferon-gamma release assay; Latent tuberculosis infection; Reversion; Aged; Female; Humans; Interferon-gamma Release Tests; Latent Tuberculosis; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Renal Dialysis | - |
dc.title | Dynamic changes in positive interferon-gamma release assay in a dialysis population: An observational cohort study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jinf.2013.07.029 | - |
dc.identifier.pmid | 23933475 | - |
dc.identifier.scopus | 2-s2.0-84887016600 | - |
dc.relation.pages | 529-535 | - |
dc.relation.journalvolume | 67 | - |
dc.relation.journalissue | 6 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine-NTUHYL | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Center for Infection Control | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Center for Infection Control | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | National Taiwan University Hospital Hsin-Chu Branch | - |
crisitem.author.dept | NTU BioMedical Park Hospital | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-0311-5148 | - |
crisitem.author.orcid | 0000-0001-7935-0991 | - |
crisitem.author.orcid | 0000-0003-1235-1943 | - |
crisitem.author.orcid | 0000-0001-5785-0733 | - |
crisitem.author.orcid | 0000-0003-3154-6690 | - |
crisitem.author.orcid | 0000-0003-3406-366X | - |
crisitem.author.orcid | 0000-0002-0924-3469 | - |
crisitem.author.orcid | 0000-0001-5664-9392 | - |
crisitem.author.orcid | 0000-0002-7654-2450 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Hsin-Chu Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
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