https://scholars.lib.ntu.edu.tw/handle/123456789/512585
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | LUN-CHE CHEN | en_US |
dc.contributor.author | JIN-YUAN SHIH | en_US |
dc.contributor.author | CHONG-JEN YU | en_US |
dc.contributor.author | Yang C.-Y. | en_US |
dc.creator | Chen L.-C.;Jin-Yuan Shih;Yu C.-J.;Yang C.-Y. | - |
dc.date.accessioned | 2020-08-13T06:33:27Z | - |
dc.date.available | 2020-08-13T06:33:27Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2051-3380 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065498754&doi=10.1002%2frcr2.425&partnerID=40&md5=8b23718132292101f19e41007b38f1dc | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/512585 | - |
dc.description.abstract | Uncommon mutations account for 10–15% of epidermal growth factor receptor (EGFR) mutations in patients with non-small-cell lung cancer. Afatinib is currently the most efficient EGFR-tyrosine kinase inhibitor (TKI) against uncommon EGFR mutations. Here we report a 56-year-old woman presenting with persistent cough for one month. She was diagnosed with stage IV lung adenocarcinoma by bronchoscopic biopsy to the left lower lung tumour and serial image modalities. A rare H773L/V774M compound mutation in exon 20 was detected by gene sequencing. The patient received first-line afatinib but primary resistance was noted with rapid left lower lung tumour progression. Second-line chemotherapy combined with bevacizumab, pemetrexed, and cisplatin demonstrated more durable response. Our case suggests that H773L/V774M may be one of the EGFR-TKI-resistant uncommon EGFR mutations. ? 2019 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology | en_US |
dc.publisher | Wiley-Blackwell Publishing Ltd | en_US |
dc.relation.ispartof | Respirology Case Reports | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | afatinib; bevacizumab; cisplatin; docetaxel; epidermal growth factor receptor; pemetrexed; protein tyrosine kinase inhibitor; ramucirumab; adaptive immunity; adrenal gland; adult; Article; biopsy; bronchoscopy; case report; clinical article; coughing; disease exacerbation; DNA extraction; evaluation and follow up; exon; female; gene mutation; gene sequence; human; lung adenocarcinoma; lung metastasis; mediastinum lymph node; middle aged; multiple cycle treatment; non small cell lung cancer; radiation dose; supraclavicular lymph node; tumor growth; whole brain radiotherapy | - |
dc.title | A rare epidermal growth factor receptor H773L/V774M compound mutation in advanced non-small-cell lung cancer with poor response to epidermal growth factor receptor tyrosine kinase inhibitor | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/rcr2.425 | - |
dc.identifier.scopus | 2-s2.0-85065498754 | - |
dc.relation.pages | e00425 | en_US |
dc.relation.journalvolume | 7 | en_US |
dc.relation.journalissue | 5 | en_US |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | National Taiwan University Hospital Hsin-Chu Branch | - |
crisitem.author.dept | NTU BioMedical Park Hospital | - |
crisitem.author.orcid | 0000-0001-9938-9762 | - |
crisitem.author.orcid | 0000-0002-2854-5067 | - |
crisitem.author.orcid | 0000-0001-5664-9392 | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Hsin-Chu Branch | - |
顯示於: | 醫學系 |
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