https://scholars.lib.ntu.edu.tw/handle/123456789/512677
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yuan S. | en_US |
dc.contributor.author | SUNG-LIANG YU | en_US |
dc.contributor.author | Chen H.-Y. | en_US |
dc.contributor.author | Hsu Y.-C. | en_US |
dc.contributor.author | KANG-YI SU | en_US |
dc.contributor.author | HUEI-WEN CHEN | en_US |
dc.contributor.author | Chen C.-Y. | en_US |
dc.contributor.author | CHONG-JEN YU | en_US |
dc.contributor.author | JIN-YUAN SHIH | en_US |
dc.contributor.author | YIH-LEONG CHANG | en_US |
dc.contributor.author | Cheng C.-L. | en_US |
dc.contributor.author | Hsu C.-P. | en_US |
dc.contributor.author | Hsia J.-Y. | en_US |
dc.contributor.author | Lin C.-Y. | en_US |
dc.contributor.author | Wu G. | en_US |
dc.contributor.author | Liu C.-H. | en_US |
dc.contributor.author | Wang C.-D. | en_US |
dc.contributor.author | Yang K.-C. | en_US |
dc.contributor.author | Chen Y.-W. | en_US |
dc.contributor.author | Lai Y.-L. | en_US |
dc.contributor.author | Hsu C.-C. | en_US |
dc.contributor.author | Lin T.-C. | en_US |
dc.contributor.author | Yang T.-Y. | en_US |
dc.contributor.author | Chen K.-C. | en_US |
dc.contributor.author | Hsu K.-H. | en_US |
dc.contributor.author | Chen J.J.W. | en_US |
dc.contributor.author | Chang G.-C. | en_US |
dc.contributor.author | Li K.-C. | en_US |
dc.contributor.author | PAN-CHYR YANG | en_US |
dc.creator | Yuan S.;Yu S.-L.;Chen H.-Y.;Hsu Y.-C.;Su K.-Y.;Chen H.-W.;Chen C.-Y.;Yu C.-J.;Jin-Yuan Shih;Chang Y.-L.;Cheng C.-L.;Hsu C.-P.;Hsia J.-Y.;Lin C.-Y.;Wu G.;Liu C.-H.;Wang C.-D.;Yang K.-C.;Chen Y.-W.;Lai Y.-L.;Hsu C.-C.;Lin T.-C.;Yang T.-Y.;Chen K.-C.;Hsu K.-H.;Chen J.J.W.;Chang G.-C.;Li K.-C.;Yang P.-C. | - |
dc.date.accessioned | 2020-08-13T06:33:51Z | - |
dc.date.available | 2020-08-13T06:33:51Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0732-183X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052691368&doi=10.1200%2fJCO.2011.35.3979&partnerID=40&md5=d5606d4e89f8ea32d677fdabc428f7fa | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/512677 | - |
dc.description.abstract | Purpose: Although epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been proven more effective for patients with lung adenocarcinoma with EGFR-activating mutation rather than wild type, the former group still includes approximately 30% nonresponders. The molecular basis of this substantial response heterogeneity is unknown. Our purpose was to seek molecular aberrations contributing to disease progression at the genome-wide level and identify the prognostic signature unique to patients with EGFR-activating mutation. Patients and Methods: We first investigated the molecular differences between tumors with EGFR-activating mutation and wild-type tumors by conducting high-density array comparative genomic hybridization on a collection of 138 adenocarcinoma tissues. We then used an independent group of 114 patients to validate the clinical relevance of copy-number alterations (CNAs) in predicting overall and disease-free survival. Finally, focusing on 23 patients with EGFR mutation receiving EGFR-TKI treatment, we investigated the association between CNAs and response to EGFR-TKIs. Results: We identified chromosome regions with differential CNAs between tumors with EGFR-activating mutation and wild-type tumors and found the aberration sites to cluster highly on chromosome 7p. A cluster of six representative chromosome 7p genes predicted overall and disease-free survival for patients with EGFR-activating mutation but not for those with wild type. Importantly, simultaneous presence of more genes with increased CNAs in this cluster correlated with less favorable response to EGFR-TKIs in patients with EGFR-activating mutation. Conclusion: Our results shed light on why responses to EGFR-TKIs are heterogeneous among patients with EGFR-activating mutation. They may lead to better patient management in this population. ? 2011 by American Society of Clinical Oncology. | - |
dc.relation.ispartof | Journal of Clinical Oncology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | epidermal growth factor receptor; erlotinib; gefitinib; adult; article; cancer tissue; chromosome 7p; chromosome aberration; chromosome mutation; comparative genomic hybridization; controlled study; copy number variation; disease course; disease free survival; female; gene; gene cluster; genetic association; human; human cell; human tissue; lung adenocarcinoma; major clinical study; male; overall survival; priority journal; treatment outcome; treatment response; wild type; Adenocarcinoma; Aged; Carcinoma, Non-Small-Cell Lung; Chromosome Aberrations; Chromosomes, Human, Pair 7; Comparative Genomic Hybridization; DNA Mutational Analysis; DNA, Neoplasm; Female; Follow-Up Studies; Gene Dosage; Genome, Human; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Polymerase Chain Reaction; Prognosis; Protein Kinase Inhibitors; Receptor, Epidermal Growth Factor; Survival Rate | - |
dc.title | Clustered genomic alterations in chromosome 7p dictate outcomes and targeted treatment responses of lung adenocarcinoma with EGFR-activating mutations | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1200/JCO.2011.35.3979 | - |
dc.identifier.pmid | 21810691 | - |
dc.identifier.scopus | 2-s2.0-80052691368 | - |
dc.relation.pages | 3435-3442 | - |
dc.relation.journalvolume | 29 | - |
dc.relation.journalissue | 25 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Medical Device and Imaging | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Toxicology | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | National Taiwan University Hospital Hsin-Chu Branch | - |
crisitem.author.dept | NTU BioMedical Park Hospital | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Pathology-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-4535-9036 | - |
crisitem.author.orcid | 0000-0002-6538-9526 | - |
crisitem.author.orcid | 0000-0001-5051-9896 | - |
crisitem.author.orcid | 0000-0001-5664-9392 | - |
crisitem.author.orcid | 0000-0002-2854-5067 | - |
crisitem.author.orcid | 0000-0001-5309-0554 | - |
crisitem.author.orcid | 0000-0001-6330-6048 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Hsin-Chu Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
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