https://scholars.lib.ntu.edu.tw/handle/123456789/512874
標題: | Standardized uptake value and apparent diffusion coefficient of endometrial cancer evaluated with integrated whole-body PET/MR: Correlation with pathological prognostic factors | 作者: | I-LUN SHIH RUOH-FANG YEN CHI-AN CHEN BANG-BIN CHEN Wei S.-Y. WEN-CHUN CHANG BOR-CHING SHEU WEN-FANG CHENG YAO-HUI TSENG Chen X.-J. CHI-HAU CHEN LING-HUNG WEI YING-CHENG CHIANG PAO-LING TORNG MEN-LUH YEN TIFFANY TING-FANG SHIH |
公開日期: | 2015 | 卷: | 42 | 期: | 6 | 起(迄)頁: | 1723-1732 | 來源出版物: | Journal of Magnetic Resonance Imaging | 摘要: | Purpose To evaluate the correlation between maximum standardized uptake value (SUVmax) and minimum apparent diffusion coefficient (ADCmin) of endometrial cancer derived from an integrated positron emission tomography / magnetic resonance (PET/MR) system and to determine their correlation with pathological prognostic factors. Materials and Methods This prospective study was approved by the Institutional Review Board of the hospital, and informed consent was obtained. Between April and December 2014, 47 consecutive patients with endometrial cancer were enrolled and underwent simultaneous PET/MR examinations before surgery. Thirty-six patients with measurable tumors on PET/MR were included for image analysis. Pearson's correlation coefficient was used to evaluate the correlation between SUVmax and ADCmin of the tumors. The Mann-Whitney U-test was utilized to evaluate relationships between these two imaging biomarkers and pathological prognostic factors. Results The mean SUVmax and ADCmin were 14.7 ± 7.1 and 0.48 ± 0.13 × 10-3 mm2/s, respectively. A significant inverse correlation was found between SUVmax and ADCmin (r = -0.53; P = 0.001). SUVmax was significantly higher in tumors with advanced stage, deep myometrial invasion, cervical invasion, lymphovascular space involvement, and lymph node metastasis (P < 0.05). ADCmin was lower in tumors with higher grade, advanced stage, and cervical invasion (P < 0.05). The ratio of SUVmax to ADCmin was higher in tumors with higher grade, advanced stage, deep myometrial invasion, cervical invasion, lymphovascular space involvement, and lymph node metastasis (P < 0.05). Conclusion SUVmax and ADCmin of endometrial cancer derived from integrated PET/MR are inversely correlated and are associated with pathological prognostic factors. ? 2015 Wiley Periodicals, Inc. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/512874 | DOI: | 10.1002/jmri.24932 | SDG/關鍵字: | biological marker; fluorodeoxyglucose f 18; gadoterate meglumine; fluorodeoxyglucose f 18; radiopharmaceutical agent; adult; aged; apparent diffusion coefficient; Article; cancer grading; cancer prognosis; cancer staging; clinical article; computer assisted emission tomography; contrast enhancement; controlled study; diagnostic accuracy; diffusion coefficient; disease association; endometrium cancer; female; human; image analysis; lymph node metastasis; priority journal; prospective study; radiological parameters; receiver operating characteristic; standardized uptake value; tumor volume; uterine cervix carcinoma; very elderly; whole body imaging; biological model; clinical trial; computer assisted diagnosis; computer simulation; diffusion weighted imaging; Endometrial Neoplasms; image enhancement; metabolic clearance rate; middle aged; multimodal imaging; positron emission tomography; prevalence; procedures; prognosis; reproducibility; risk factor; sensitivity and specificity; statistics; system analysis; Adult; Aged; Aged, 80 and over; Computer Simulation; Diffusion Magnetic Resonance Imaging; Endometrial Neoplasms; Female; Fluorodeoxyglucose F18; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Metabolic Clearance Rate; Middle Aged; Models, Biological; Multimodal Imaging; Positron-Emission Tomography; Prevalence; Prognosis; Radiopharmaceuticals; Reproducibility of Results; Risk Factors; Sensitivity and Specificity; Statistics as Topic; Systems Integration; Whole Body Imaging |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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