https://scholars.lib.ntu.edu.tw/handle/123456789/513430
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Bose A. | en_US |
dc.contributor.author | Hartmann M. | en_US |
dc.contributor.author | Henkes H. | en_US |
dc.contributor.author | HON-MAN LIU | en_US |
dc.contributor.author | Teng M.M.H. | en_US |
dc.contributor.author | Szikora I. | en_US |
dc.contributor.author | Berlis A. | en_US |
dc.contributor.author | Reul J. | en_US |
dc.contributor.author | Yu S.C.H. | en_US |
dc.contributor.author | Forsting M. | en_US |
dc.contributor.author | Lui M. | en_US |
dc.contributor.author | Lim W. | en_US |
dc.contributor.author | Sit S.P. | en_US |
dc.creator | Bose A.;Hartmann M.;Henkes H.;Hon-Man Liu;Teng M.M.H.;Szikora I.;Berlis A.;Reul J.;Yu S.C.H.;Forsting M.;Lui M.;Lim W.;Sit S.P. | - |
dc.date.accessioned | 2020-08-21T08:51:10Z | - |
dc.date.available | 2020-08-21T08:51:10Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0039-2499 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/513430 | - |
dc.description.abstract | BACKGROUND AND PURPOSE - The purpose of this study was to assess the safety and performance of the Wingspan stent system and Gateway percutaneous transluminal angioplasty balloon catheter in the treatment of high-grade, intracranial atherosclerotic lesions in patients who had failed medical therapy. METHODS - In this prospective, multicenter, single-arm study, medically refractory patients with a modified Rankin score ?3 and recurrent symptoms attributable to angiographically demonstrated intracranial stenosis ?50% in a vessel 2.5 to 4.5 mm in diameter were enrolled. Intracranial lesions were predilated with an undersized Gateway balloon catheter to 80% of the native vessel diameter, followed by deployment of the self-expanding Wingspan stent to facilitate further remodeling of the atherosclerotic plaque and to maintain vessel patency. Neurologic examinations and angiograms were performed at 6 months after the procedure. RESULTS - Among the 45 patients enrolled, the degree of stenosis was reduced from a baseline of 74.9±9.8% to 31.9±13.6% after stenting and 28±23.2% at the 6-month follow-up. The 30-day composite ipsilateral stroke/death rate was 4.5% (2/44); at the 6-month follow-up, the ipsilateral stroke/death rate was 7.0%, the rate for all strokes was 9.7%, and all-cause mortality was 2.3%. Physician-reported follow-up in 43 patients (average of 13 months) conducted outside the study protocol (not adjudicated by the clinical event committee) reported 1 additional ipsilateral stroke. CONCLUSIONS - In medically refractory patients with high-grade intracranial atherosclerotic stenoses, a new treatment paradigm involving predilation with an undersized Gateway percutaneous transluminal angioplasty balloon catheter and placement of a self-expanding Wingspan stent system appears to be safe, may facilitate remodeling, and may contribute to favorable angiographic outcomes. ? 2007 American Heart Association, Inc. | - |
dc.relation.ispartof | Stroke | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | acetylsalicylic acid; clopidogrel; nitinol; adverse outcome; aged; article; atherosclerotic plaque; balloon catheter; blood vessel; blood vessel diameter; brain atherosclerosis; brain damage; brain hematoma; clinical article; clinical trial; controlled clinical trial; controlled study; epiglottis edema; female; fever; follow up; heart arrhythmia; human; hyperglycemia; hypertension; hypervolemia; male; mortality; multicenter study; neurologic examination; nystagmus; percutaneous transluminal angioplasty; physician; postoperative complication; priority journal; prospective study; Rankin scale; respiratory failure; risk assessment; scoring system; stent; stroke; symptom; vascular patency; Aged; Alloys; Angioplasty, Balloon; Female; Humans; Intracranial Arteriosclerosis; Male; Prospective Studies; Stents; Treatment Outcome | - |
dc.title | A novel, self-expanding, nitinol stent in medically refractory intracranial atherosclerotic stenoses: The Wingspan study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1161/STROKEAHA.106.477711 | - |
dc.identifier.pmid | 17395864 | - |
dc.identifier.scopus | 2-s2.0-34247573435 | - |
dc.relation.pages | 1531-1537 | - |
dc.relation.journalvolume | 38 | - |
dc.relation.journalissue | 5 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.orcid | 0000-0001-6715-6366 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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