https://scholars.lib.ntu.edu.tw/handle/123456789/513457
Title: | Diffusion tensor images in children with early-treated, chronic, malignant phenylketonuric: Correlation with intelligence assessment | Authors: | STEVEN SHINN-FORNG PENG WEN-YIH TSENG YIN-HSIU CHIEN WUH-LIANG HWU HON-MAN LIU |
Issue Date: | 2004 | Journal Volume: | 25 | Journal Issue: | 9 | Start page/Pages: | 1569-1574 | Source: | American Journal of Neuroradiology | Abstract: | BACKGROUND AND PURPOSE: Diffusion tensor (DT) images can provide information about the nature of white matter changes, including axonal loss and demyelination. We applied DT imaging to verify white matter changes in patients with malignant phenylketonuria (PKU) and to correlate the findings with clinical intelligence quotients (IQs). METHODS: We compared DT images with T2-weighted images in 12 patients with early-treated, chronic, stable malignant PKU and 12 age-matched control subjects. DT parameters included first, second, and third eigenvalues (EV1-3), apparent diffusion coefficients (ADCs), and fractional anisotropy (FA). Regions of interest were placed the frontoparietal, parietooccipital, frontal and central white matter and in the anterior and posterior corpus callosum. Eight patients older than 3 years underwent IQ assessment including verbal, performance, and full-scale IQ tests. RESULTS: In the eight patients older than 3 years, no definite abnormal signal intensity changes were found on T2-weighted images. EV2, EV3, and FA of the parieto-occipital white matter were significantly different in patients and control subjects older than 3 years. EV3 and ADC of the parieto-occipital white matter were significantly and negatively correlated with verbal IQ (r = -0.79, P = .04) and performance IQ (r = -0.93, P = .03). FA of the parieto-occipital central white matter was positively correlated with verbal IQ (r = 0.75, P = .05). CONCLUSION: Though treated early, patients with chronic, stable malignant PKU had abnormal DT findings in the parieto-occipital central white matter. EV2, EV3, and FA maps are potential tools for demonstrating brain changes due to malignant PKU. ? American Society of Neuroradiology. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/513457 | ISSN: | 0195-6108 | SDG/Keyword: | anisotropy; article; child; chronic disease; clinical article; controlled study; corpus callosum; correlation analysis; demyelination; diffusion coefficient; diffusion tensor imaging; human; intelligence quotient; intelligence test; performance; phenylketonuria; white matter; brain cortex; chronic brain disease; comparative study; corpus callosum; diffusion weighted imaging; female; follow up; hemispheric dominance; infant; intelligence; male; multimodality cancer therapy; myelinated nerve; nerve fiber; newborn; newborn screening; pathology; phenylketonuria; physiology; pregnancy; preschool child; 5 hydroxytryptophan; 5,6,7,8-tetrahydrobiopterin; biopterin; drug derivative; levodopa; phenylalanine; tetrahydrobiopterin; 5-Hydroxytryptophan; Axons; Biopterin; Brain Damage, Chronic; Cerebral Cortex; Child; Child, Preschool; Combined Modality Therapy; Corpus Callosum; Diffusion Magnetic Resonance Imaging; Dominance, Cerebral; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Intelligence; Levodopa; Male; Neonatal Screening; Nerve Fibers, Myelinated; Phenylalanine; Phenylketonurias; Pregnancy |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.