https://scholars.lib.ntu.edu.tw/handle/123456789/513573
Title: | Wide-scope screening for pharmaceutically active substances in a leafy vegetable cultivated under biogas slurry irrigation | Authors: | WEN-LING CHEN Sheng-Chi Lin Chih-Hsuan Huang Shao-Yu Peng Yee Soon Ling |
Keywords: | Biogas slurry; High-resolution mass spectrometry; Suspect screening; Vegetables; Veterinary drugs | Issue Date: | Jan-2021 | Publisher: | elsevier | Journal Volume: | 750 | Source: | Science of The Total Environment | Abstract: | The use of livestock waste for the production of biogas and the application of biogas slurry to agricultural soil can resolve livestock waste problems and reduce synthetic fertiliser use. However, the migration of veterinary drugs to land and crops resulting from biogas slurry irrigation is a potential food safety concern. This study employed an ultra-performance liquid chromatography coupled with quadrupole-time of flight high-resolution mass spectrometry system for wide-scope suspect screening of pharmaceutically active substances on crop cultivated under biogas slurry irrigation. Briefly, a total of 22 pak choi samples were obtained from a greenhouse farmed in tropical south Taiwan between March 2019 and March 2020. Molecular spectra and fragmented ions (between m/z 70 and 1100) were acquired. Ion features were searched and matched with a library consisting of 1068 compounds. The matrixes in the crop production environment including soil, livestock wastewater, biogas slurry, and groundwater were included in this study to elucidate potential sources of the pharmaceutically active substances. Results demonstrated 23 suspects were matched with high mass accuracy (mass error within ±5.0 ppm) in pak choi. The detection of both bufexamac and nandrolone were confirmed using standards, where a new system of identification points was applied. Nandrolone was detected throughout the pak choi samples as well as livestock wastewater. Tetracycline, macrolide, and sulfonamide antibiotics were presented in biogas slurry and soil but not pak choi. This is the first study to reveal the presence of multiclass pharmaceutically active substances in a crop supplied as food. Such findings suggest that anabolics and antibiotics should be closely monitored in the corps irrigated by biogas slurry in future. © 2020 Elsevier B.V. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/513573 | ISSN: | 00489697 | DOI: | 10.1016/j.scitotenv.2020.141519 | SDG/Keyword: | Agricultural robots; Antibiotics; Crops; Cultivation; Groundwater; Irrigation; Liquid chromatography; Mass spectrometry; Molecular spectroscopy; Soils; Sulfur compounds; High mass accuracies; High resolution mass spectrometry; Identification point; Livestock wastewater; Quadrupole-time of flights; Sulfonamide antibiotics; Ultra performance liquid chromatography; Wide-scope screenings; Biogas; antibiotic agent; bufexamac; etamivan; ethotoin; ground water; ion; macrolide; nandrolone; sulfonamide; tetracycline; veterinary drug; biofuel; fertilizer; agricultural soil; biogas; drug; food safety; irrigation system; leafy vegetable; mass spectrometry; slurry; agricultural land; agricultural slurry; agricultural waste; analytical error; Article; bok choy; controlled study; crop production; cultivated species; drug identification; drug screening; food contamination; gas; greenhouse; irrigation (agriculture); leafy vegetable; livestock; mass spectrometry; measurement accuracy; nonhuman; priority journal; quadrupole mass spectrometry; Taiwan; time of flight mass spectrometry; ultra performance liquid chromatography; waste water; soil; vegetable; Brassica rapa subsp. chinensis; Biofuels; Fertilizers; Soil; Taiwan; Vegetables |
Appears in Collections: | 食品安全與健康研究所 |
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