https://scholars.lib.ntu.edu.tw/handle/123456789/514321
Title: | Magnetic resonance cholangiography for evaluation of cholestatic jaundice neonates and infants | Authors: | STEVEN SHINN-FORNG PENG Li Y.-W. MEI-HWEI CHANG YEN-HSUAN NI Su C.-T. |
Issue Date: | 1998 | Journal Volume: | 97 | Journal Issue: | 10 | Start page/Pages: | 698-703 | Source: | Journal of the Formosan Medical Association | Abstract: | Distinguishing extrahepatic biliary atresia from other causes of cholestasis in neonates and infants is important because surgical intervention before 2 months of age allows for long-term survival. The purpose of this prospective study was to evaluate the usefulness of magnetic resonance (MR) cholangiography in differentiating biliary atresia from other causes of cholestatic jaundice in neonates and infants. Nine anicteric infants (control group) aged 10 to 224 days (mean ± SD, 8 ± 65 days) and 15 neonates and infants with cholestatic jaundice, aged 22 to 142 days (mean ± SD, 71 ± 37) underwent MR cholangiography. The final diagnosis of extrabiliary atresia (6 patients) was based on laparotomy findings (4 patients) or autopsy (2 patients), while neonatal hepatitis (9 patients) was diagnosed according to the liver biopsy findings and clinical recovery during follow-up. Percutaneous liver biopsies were performed in all 15 patient. Results showed that the gall bladder and common bile duct (CBD) could be visualized using MR cholangiography in all patients in the control group. Nonvisualization of the CBD (6/6 patients) and demonstration of a small gall bladder (6/6 patients) characterized MR cholangiography findings in patients with biliary atresia. MR cholangiography failed to depict the CBD in one infant with hepatitis. We conclude that demonstration of the CBD by MR cholangiography in neonates and infants with cholestasis can be used to exclude the diagnosis of biliary atresia. In patients with cholestatic jaundice considered for exploratory laparotomy, preoperative MR cholangiography is recommended to avoid unnecessary surgery. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/514321 | ISSN: | 0929-6646 | SDG/Keyword: | article; bile duct atresia; cholangiography; clinical article; diagnostic accuracy; diagnostic imaging; diagnostic value; differential diagnosis; female; human; liver biopsy; male; newborn; newborn disease; nuclear magnetic resonance; obstructive jaundice; Biliary Atresia; Cholestasis; Common Bile Duct; Diagnosis, Differential; Female; Gallbladder; Humans; Infant; Infant, Newborn; Magnetic Resonance Imaging; Male; Prospective Studies |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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