https://scholars.lib.ntu.edu.tw/handle/123456789/514398
Title: | Clinical significance of quantitative assessment of glucose utilization in patients with ischemic cardiomyopathy | Authors: | KUAN-YIN KO Wang S.-Y. RUOH-FANG YEN Shiau Y.-C. Hsu J.-C. Tsai H.-Y. Lee C.-L. Chiu K.-M. YEN-WEN WU |
Issue Date: | 2020 | Journal Volume: | 27 | Journal Issue: | 1 | Start page/Pages: | 269-279 | Source: | Journal of Nuclear Cardiology | Abstract: | Background: The aim of this study was to prospectively quantify the rate of myocardial glucose uptake (MRGlu) in myocardium with different perfusion-metabolism patterns and determine its prognostic value in patients with ischemic cardiomyopathy. Methods and Results: 79 patients with ischemic cardiomyopathy were prospectively enrolled for dynamic cardiac FDG PET, and then followed for at least 6?months. Perfusion-metabolism patterns were determined based on visual score analysis of 201Tl SPECT and FDG PET. MRGlu was analyzed using the Patlak kinetic model. The primary end-point was cardiovascular mortality. Significantly higher MRGlu was observed in viable compared with non-viable areas. Negative correlations were found between MRGlu in transmural match and a history of hyperlipidemia, statin usage, and triglyceride levels. Diabetic patients receiving dipeptidyl peptidase-4 inhibitors (DPP4i) had a significantly lower MRGlu in transmural match, mismatch, and reverse mismatch. Patients with MRGlu in transmural match ??23.40 or reverse mismatch ??36.90 had a worse outcome. Conclusions: Myocardial glucose utilization was influenced by substrates and medications, including statins and DPP4i. MRGlu could discriminate between viable and non-viable myocardium, and MRGlu in transmural match and reverse mismatch may be prognostic predictors of cardiovascular death in patients with ischemic cardiomyopathy. ? 2018, American Society of Nuclear Cardiology. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/514398 | ISSN: | 1071-3581 | DOI: | 10.1007/s12350-018-1395-4 | SDG/Keyword: | acetylsalicylic acid; aminophylline; clopidogrel; creatinine; dipeptidyl peptidase IV inhibitor; dipyridamole; fluorodeoxyglucose f 18; glucose; hemoglobin A1c; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; thallium 201; fluorodeoxyglucose f 18; glucose; radiopharmaceutical agent; adult; Article; cardiac gated imaging; cardiac muscle; cardiovascular mortality; cohort analysis; controlled study; coronary angiography; correlational study; diabetic patient; female; glucose blood level; glucose transport; glucose utilization; heart muscle ischemia; human; hyperlipidemia; image quality; ischemic cardiomyopathy; limit of quantitation; major clinical study; male; middle aged; positron emission tomography; priority journal; prognosis; prospective study; quantitative analysis; scar formation; single photon emission computed tomography; transthoracic echocardiography; triacylglycerol level; aged; diagnostic imaging; heart muscle ischemia; metabolism; very elderly; Adult; Aged; Aged, 80 and over; Cohort Studies; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardium; Positron-Emission Tomography; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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