https://scholars.lib.ntu.edu.tw/handle/123456789/514549
標題: | High prevalence of asymptomatically poor muscle perfusion of lower extremities measured in type II diabetes patients with abnormal myocardial perfusion | 作者: | Lin C.-C. Ding H.-J. RUOH-FANG YEN Wang J.-J. Ho S.-T. Kao A. |
公開日期: | 2003 | 卷: | 17 | 期: | 6 | 起(迄)頁: | 365-368 | 來源出版物: | Journal of Diabetes and its Complications | 摘要: | Foot problems are the most common cause of hospital admission in patients with type II diabetes mellitus (DM). Poor muscle perfusion of lower extremities is thought to be the major component in the pathogenesis of foot problems. Therefore, it is important and interesting to investigate if high prevalence of poor muscle perfusion of lower extremities in type II DM patients with abnormal myocardial perfusion and more cardiovascular risk factors. We used a well-established and noninvasive radionuclide method (Xe-133 muscle washout) to objectively evaluate the anterior tibial muscle perfusion of 60 type II DM male patients without symptoms/signs of peripheral vascular disease (PVD) in the lower extremities. The patients were separated into groups according to the myocardial perfusion imaging results and cardiovascular risk factor survey. Meanwhile, 30 normal male controls with a matched age distribution were also included for comparison. The muscle perfusions were of significant difference (P-values <.05) between (1) 60 type II DM patients (1.84±0.43 ml/100 g/min) and 30 normal controls (2.95±0.52 ml/100 g/min), (2) 24 patients with abnormal myocardial perfusion (1.31±0.45 ml/100 g/min) and 36 patients with normal myocardial perfusion (2.24±0.48 ml/100 g/min), as well as (3) 28 patients with more cardiovascular risk factors (1.33±0.46 ml/100 g/min) and 22 patient with less cardiovascular risk factors (2.22±0.49 ml/100 g/min). Based on Xe-133 muscle washout method, we concluded that the muscle perfusion in the lower extremities of type II DM patients without symptoms/signs of PVD is significantly decreased and related to abnormal myocardial perfusion and more cardiovascular risk factors. ? 2003 Elsevier Inc. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/514549 | ISSN: | 1056-8727 | DOI: | 10.1016/S1056-8727(02)00244-1 | SDG/關鍵字: | radioisotope; technetium 99m; xenon 133; adult; aged; arteriography; article; cardiovascular risk; cigarette smoking; clinical study; controlled study; creatinine clearance; disease duration; dyslipidemia; evaluation; heart muscle perfusion; human; hypertension; leg muscle; major clinical study; male; muscle perfusion; non insulin dependent diabetes mellitus; peripheral vascular disease; prevalence; priority journal; risk assessment; risk factor; statistical analysis; statistical significance; symptomatology; tibialis anterior muscle |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。