https://scholars.lib.ntu.edu.tw/handle/123456789/514559
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Shen Y.-Y. | en_US |
dc.contributor.author | Kao A. | en_US |
dc.contributor.author | RUOH-FANG YEN | en_US |
dc.creator | Shen Y.-Y.;Kao A.;Ruoh-Fang Yen | - |
dc.date.accessioned | 2020-09-23T06:22:49Z | - |
dc.date.available | 2020-09-23T06:22:49Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/514559 | - |
dc.description.abstract | This study evaluates and compares the accuracy of positron emission tomography with 18F-fluoro-2-deoxyglucose (FDG-PET) and gallium-67 citrate (Ga-67) scintigraphy in identifying disease sites in patients with malignant lymphoma at initial diagnosis or relapse. Histology subgroups included low (n=5), intermediate (n=6), high-grade (n=5) non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD) (n=14). Ann-Arbor staging included 7 patients in stage I, 8 in stage II, 9 in stage II, 6 in stage IV and 11 extra-nodal. In this study, before any therapy, 25 contemporaneous FDG-PET and Ga-67 scintigraphies were performed on patients with either NHL (16) or HD (14). One hundred and eleven sites of disease were correlated on a site-by-site basis in corresponding areas of FDG-PET and Ga-67 scintigraphy. Discordant FDG-PET and Ga-67 scintigraphic findings were correlated with CT/MRI and clinical evaluation. FDG-PET detected malignant lymphoma in 24/25 patients (sensitivity: 96.0%). There was a false-negative FDG-PET result in only 1 patient with low-grade gastric malignant lymphoma. Ga-67 scintigraphy detected malignant lymphoma in 18/25 patients (sensitivity: 72.0%). There were false-negative Ga-67 scintigraphic results in 4 cases with low-grade non-Hodgkin's lymphoma, 2 cases with bone or bone marrow involvement, and 3 smaller disease sites. FDG-PET upstaged 6 patients in whom Ga-67 scintigraphy detected disease sites partially. In imaging lymphoma prior to therapy, FDG-PET had a higher sensitivity and detected significantly more disease sites when compared with Ga-67 scintigraphy in the initial evaluation of this group of patients. Upstaging of patients with FDG-PET may result in a change in treatment strategy. However, evaluation of the final sensitivity, specificity and accuracy of these imaging modalities will need a further study with a larger patient number. | - |
dc.relation.ispartof | Oncology Reports | - |
dc.subject | 18F-fluoro-2-deoxyglucose positron emission tomography; Gallium-67 citrate scintigraphy; Malignant lymphoma | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | diagnostic agent; fluorodeoxyglucose f 18; gallium; radiopharmaceutical agent; adult; aged; article; cancer staging; comparative study; computer assisted emission tomography; differential diagnosis; female; Hodgkin disease; human; male; methodology; middle aged; nonhodgkin lymphoma; scintiscanning; sensitivity and specificity; Adult; Aged; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Gallium Radioisotopes; Hodgkin Disease; Humans; Lymphoma, Non-Hodgkin; Male; Middle Aged; Neoplasm Staging; Radiopharmaceuticals; Sensitivity and Specificity; Tomography, Emission-Computed | - |
dc.title | Comparison of 18F-fluoro-2-deoxyglucose positron emission tomography and gallium-67 citrate scintigraphy for detecting malignant lymphoma | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3892/or.9.2.321 | - |
dc.identifier.pmid | 11836600 | - |
dc.identifier.scopus | 2-s2.0-0036511413 | - |
dc.relation.pages | 321-325 | - |
dc.relation.journalvolume | 9 | - |
dc.relation.journalissue | 2 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Nuclear Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-1648-6482 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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