https://scholars.lib.ntu.edu.tw/handle/123456789/514684
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JENNY LING-YU CHEN | en_US |
dc.contributor.author | YU-SEN HUANG | en_US |
dc.contributor.author | SUNG-HSIN KUO | en_US |
dc.contributor.author | YA-FANG CHEN | en_US |
dc.contributor.author | RUEY-LONG HONG | en_US |
dc.contributor.author | JENG-YUH KO | en_US |
dc.contributor.author | PEI-JEN LOU | en_US |
dc.contributor.author | CHIAO-LING TSAI | en_US |
dc.contributor.author | WAN-YU CHEN | en_US |
dc.contributor.author | CHUN-WEI WANG | en_US |
dc.creator | Chen J.L.-Y.;Huang Y.-S.;Kuo S.-H.;Ya-Fang Chen;Hong R.-L.;Ko J.-Y.;Lou P.-J.;Tsai C.-L.;Chen W.-Y.;Wang C.-W. | - |
dc.date.accessioned | 2020-09-23T08:35:50Z | - |
dc.date.available | 2020-09-23T08:35:50Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0179-7158 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/514684 | - |
dc.description.abstract | Purpose: The purpose of this work was to examine outcomes in patients with T4 nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT). Methods and materials: Between 2007 and 2010, 154 patients with nonmetastatic T4 NPC were treated with IMRT to a total dose of 70 Gy in 33-35 fractions. In addition, 97 % of patients received concurrent platinum-based chemotherapy. The median follow-up time was 52.8 months. Results: The rates of 5-year actuarial locoregional control, distant metastasis-free survival, progression free-survival, and overall survival (OS) were 81.2, 72.2, 61.9, and 78.1 %, respectively. A total of 27 patients had locoregional recurrence: 85.2 % in-field failures, 11.1 % marginal failures, and 3.7 % out-of-field failures. Fourteen patients with locoregional recurrence received aggressive treatments, including nasopharyngectomy, neck dissection, or re-irradiation, and the 5-year OS rate tended to be better (61.9 %) compared to those receiving conservative treatment (32.0 %, p = 0.051). In patients treated with 1 course of radiotherapy, grade ? 3 toxicities of ototoxicity, neck fibrosis, xerostomia, epistaxis, and radiographic temporal lobe necrosis occurred in 18.2, 9.8, 6.3, 2.1, and 5.6 % of patients, respectively. Increased ototoxicity, osteonecrosis, severe nasal bleeding, and temporal necrosis were observed in patients treated by re-irradiation. Conclusion: IMRT offers good locoregional control in patients with T4 NPC. For patients with locoregional recurrence after definitive radiotherapy, aggressive local treatment may be considered for a better outcome. ? 2013 Springer Heidelberg Berlin. | - |
dc.relation.ispartof | Strahlentherapie und Onkologie | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cisplatin; epirubicin; fluorouracil; folinic acid; mitomycin; antineoplastic agent; cisplatin; adolescent; adult; aged; artery embolism; article; bone necrosis; brain necrosis; cancer combination chemotherapy; cancer control; cancer radiotherapy; cancer recurrence; cancer surgery; cancer survival; carotid artery stenting; chemoradiotherapy; child; conservative treatment; cranial neuropathy; distant metastasis free survival; ear nose throat surgery; endoscopic surgery; epistaxis; feasibility study; female; fibrosis; follow up; human; hyperbaric oxygen; intensity modulated radiation therapy; internal carotid artery occlusion; major clinical study; male; middle aged; mucosa inflammation; multimodality cancer therapy; multiple cycle treatment; nasopharyngectomy; nasopharynx carcinoma; neck dissection; neck fibrosis; ototoxicity; outcome assessment; overall survival; potassium titanyl phosphate laser; progression free survival; radiation dermatitis; radiation dose fractionation; radiation injury; radiation necrosis; radiotherapy equipment; radiotherapy planning system; retreatment; salvage therapy; school child; soft tissue injury; temporal lobe necrosis; tracheostomy; transcatheter arterial embolism; treatment failure; very elderly; xerostomia; young adult; adjuvant chemoradiotherapy; clinical trial; computer assisted radiotherapy; disease free survival; epidemiology; mortality; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; prevalence; risk assessment; survival; survival rate; Taiwan; treatment outcome; Adolescent; Adult; Aged; Antineoplastic Agents; Chemoradiotherapy, Adjuvant; Child; Cisplatin; Disease-Free Survival; Female; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; Prevalence; Radiotherapy, Conformal; Risk Assessment; Survival Analysis; Survival Rate; Taiwan; Treatment Outcome; Young Adult | - |
dc.title | Intensity-modulated radiation therapy for T4 nasopharyngeal carcinoma: Treatment results and locoregional recurrence | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1007/s00066-013-0429-8 | - |
dc.identifier.pmid | 24158634 | - |
dc.identifier.scopus | 2-s2.0-84890926950 | - |
dc.relation.pages | 1001-1008 | - |
dc.relation.journalvolume | 189 | - |
dc.relation.journalissue | 12 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Radiation Oncology-NTUCC | - |
crisitem.author.dept | Division of Radiation Oncology | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.orcid | 0000-0001-8553-8069 | - |
crisitem.author.orcid | 0000-0003-4262-8712 | - |
crisitem.author.orcid | 0000-0003-0054-887X | - |
crisitem.author.orcid | 0000-0003-2995-9189 | - |
crisitem.author.orcid | 0000-0001-8100-7914 | - |
crisitem.author.orcid | 0000-0002-2538-558X | - |
crisitem.author.orcid | 0000-0002-3383-8593 | - |
crisitem.author.orcid | 0000-0002-3337-0652 | - |
crisitem.author.orcid | 0000-0002-2483-8292 | - |
crisitem.author.orcid | 0000-0002-2758-6027 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | Oncology-NTUH | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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