https://scholars.lib.ntu.edu.tw/handle/123456789/514740
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Pang J. | en_US |
dc.contributor.author | Chan D.C. | en_US |
dc.contributor.author | Hu M. | en_US |
dc.contributor.author | Muir L.A. | en_US |
dc.contributor.author | Kwok S. | en_US |
dc.contributor.author | Charng M.-J. | en_US |
dc.contributor.author | Florkowski C.M. | en_US |
dc.contributor.author | George P.M. | en_US |
dc.contributor.author | Lin J. | en_US |
dc.contributor.author | Loi D.D. | en_US |
dc.contributor.author | Marais A.D. | en_US |
dc.contributor.author | Nawawi H.M. | en_US |
dc.contributor.author | Gonzalez-Santos L.E. | en_US |
dc.contributor.author | TA-CHEN SU | en_US |
dc.contributor.author | Truong T.H. | en_US |
dc.contributor.author | Santos R.D. | en_US |
dc.contributor.author | Soran H. | en_US |
dc.contributor.author | Tomlinson B. | en_US |
dc.contributor.author | Yamashita S. | en_US |
dc.contributor.author | Ademi Z. | en_US |
dc.contributor.author | Watts G.F. | en_US |
dc.creator | Pang J.;Chan D.C.;Hu M.;Muir L.A.;Kwok S.;Charng M.-J.;Florkowski C.M.;George P.M.;Lin J.;Loi D.D.;Marais A.D.;Nawawi H.M.;Gonzalez-Santos L.E.;Ta-Chen Su;Truong T.H.;Santos R.D.;Soran H.;Tomlinson B.;Yamashita S.;Ademi Z.;Watts G.F. | - |
dc.date.accessioned | 2020-09-28T02:47:23Z | - |
dc.date.available | 2020-09-28T02:47:23Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1933-2874 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061756946&doi=10.1016%2fj.jacl.2019.01.009&partnerID=40&md5=4a2d5c26ce0a94e653a11e176dee4ca1 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/514740 | - |
dc.description.abstract | Background: There is a lack of information on the health care of familial hypercholesterolemia (FH). Objective: The objective of this study was to compare the health care of FH in countries of the Asia-Pacific region and Southern Hemisphere. Methods: A series of questionnaires were completed by key opinion leaders from selected specialist centers in 12 countries concerning aspects of the care of FH, including screening, diagnosis, risk assessment, treatment, teaching/training, and research; the United Kingdom (UK)was used as the international benchmark. Results: The estimated percentage of patients diagnosed with the condition was low (overall <3%)in all countries, compared with ?15% in the UK. Underdetection of FH was associated with government expenditure on health care (? = 0.667, P <.05). Opportunistic and systematic screening methods, and the Dutch Lipid Clinic Network criteria were most commonly used to detect FH; genetic testing was infrequently used. Noninvasive imaging of coronary calcium and/or carotid plaques was underutilized in risk assessment. Patients with FH were generally not adequately treated, with <30% of patients achieving guideline recommended low-density lipoprotein cholesterol targets on conventional therapies. Treatment gaps included suboptimal availability and use of lipoprotein apheresis and proprotein convertase subtilsin-kexin type 9 inhibitors. A deficit of FH registries, training programs, and publications were identified in less economically developed countries. The demonstration of cost-effectiveness for cascade screening, genetic testing, and specialized treatments were significantly associated with the availability of subsidies from the health care system (? = 0.571–0.800, P <.05). Conclusion: We identified important gaps across the continuum of care for FH, particularly in less economically developed countries. Wider implementation of primary and pediatric care, telehealth services, patient support groups, education/training programs, research activities, and health technology assessments are needed to improve the care of patients with FH in these countries. ? 2019 National Lipid Association | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.ispartof | Journal of Clinical Lipidology | - |
dc.subject | Asia-pacific region; Facilities; Familial hypercholesterolemia; Health care; Services; Southern hemisphere | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | ezetimibe; low density lipoprotein cholesterol; nicotinic acid; probucol; proprotein convertase 9; resin; low density lipoprotein cholesterol; PCSK9 protein, human; proprotein convertase 9; serine proteinase inhibitor; Article; Australia; Brazil; China; cost effectiveness analysis; familial hypercholesterolemia; genetic screening; health care cost; Hong Kong; human; Japan; lipoprotein apheresis; Malaysia; medical specialist; New Zealand; non invasive procedure; Philippines; priority journal; public expenditure; questionnaire; risk assessment; screening test; South Africa; Taiwan; United Kingdom; Viet Nam; apheresis; blood; cardiovascular disease; comparative study; complication; diet therapy; economics; familial hypercholesterolemia; health care delivery; health education; international cooperation; register; reimbursement; Blood Component Removal; Cardiovascular Diseases; Cholesterol, LDL; Delivery of Health Care; Diet Therapy; Health Care Costs; Health Education; Humans; Hyperlipoproteinemia Type II; Insurance, Health, Reimbursement; Internationality; Proprotein Convertase 9; Registries; Risk Assessment; Serine Proteinase Inhibitors | - |
dc.title | Comparative aspects of the care of familial hypercholesterolemia in the “Ten Countries Study” | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jacl.2019.01.009 | - |
dc.identifier.pmid | 30797720 | - |
dc.identifier.scopus | 2-s2.0-85061756946 | - |
dc.relation.pages | 287-300 | - |
dc.relation.journalvolume | 13 | - |
dc.relation.journalissue | 2 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Environmental and Occupational Medicine | - |
crisitem.author.dept | Environmental and Occupational Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-7523-7166 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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