https://scholars.lib.ntu.edu.tw/handle/123456789/514770
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen P.-C. | en_US |
dc.contributor.author | JIANN-SHING JENG | en_US |
dc.contributor.author | Hsu H.-C. | en_US |
dc.contributor.author | TA-CHEN SU | en_US |
dc.contributor.author | KUO-LIONG CHIEN | en_US |
dc.contributor.author | Lee Y.-T. | en_US |
dc.date.accessioned | 2020-09-28T02:47:33Z | - |
dc.date.available | 2020-09-28T02:47:33Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84968718644&doi=10.1038%2fsrep25733&partnerID=40&md5=7c4f6e8d79f79d2fdb68cde3652a108d | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/514770 | - |
dc.description.abstract | The authors investigated the association between progression of carotid atherosclerosis and incidence of cardiovascular disease in a community cohort in Taiwan. Data has rarely been reported in Asian populations. Study subjects were 1,398 participants who underwent ultrasound measures of common carotid artery intima-media thickness (IMT) and extracranial carotid artery plaque score at both 1994-1995 and 1999-2000 surveys. Cox proportional hazards model was used to assess the risk of incident cardiovascular disease. During a median follow-up of 13 years (1999-2013), 71 strokes and 68 coronary events occurred. The 5-year individual IMT change was not associated with development of cardiovascular events in unadjusted and adjusted models. Among subjects without plaque in 1994-1995, we observed elevated risk associated with presence of new plaque (plaque score >0 in 1999-2000) in a dose-response manner in unadjusted and age-and sex-adjusted models. The associations attenuated and became statistically non-significant after controlling for cardiovascular risk factors (hazard ratio [95% confidence interval] for plaque score >2 vs. 0: stroke, 1.61 [0.79-3.27], coronary events, 1.13 [0.48-2.69]). This study suggested that carotid plaque formation measured by ultrasound is associated increased risk of developing cardiovascular disease, and cardiovascular risk factors explain the associations to a large extent. | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.ispartof | Scientific Reports | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | arterial wall thickness; atherosclerotic plaque; bioassay; cardiovascular disease; carotid artery disease; disease exacerbation; female; follow up; human; male; middle aged; pathology; proportional hazards model; risk factor; Taiwan; Cardiovascular Diseases; Carotid Artery Diseases; Carotid Intima-Media Thickness; Disease Progression; Endpoint Determination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Plaque, Atherosclerotic; Proportional Hazards Models; Risk Factors; Taiwan | - |
dc.title | Carotid Atherosclerosis Progression and Risk of Cardiovascular Events in a Community in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/srep25733 | - |
dc.identifier.pmid | 27169625 | - |
dc.identifier.scopus | 2-s2.0-84968718644 | - |
dc.relation.pages | 25733 | - |
dc.relation.journalvolume | 6 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Environmental and Occupational Medicine | - |
crisitem.author.dept | Environmental and Occupational Medicine-NTUH | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.orcid | 0000-0002-1456-3686 | - |
crisitem.author.orcid | 0000-0001-7523-7166 | - |
crisitem.author.orcid | 0000-0003-4979-8351 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
顯示於: | 醫學系 |
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