https://scholars.lib.ntu.edu.tw/handle/123456789/514781
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin C.-Y. | en_US |
dc.contributor.author | LIAN-YU LIN | en_US |
dc.contributor.author | Chen Y.-C. | en_US |
dc.contributor.author | Wen L.-L. | en_US |
dc.contributor.author | KUO-LIONG CHIEN | en_US |
dc.contributor.author | Sung F.-C. | en_US |
dc.contributor.author | PAU-CHUNG CHEN | en_US |
dc.contributor.author | TA-CHEN SU | en_US |
dc.creator | Lin C.-Y.;Lin L.-Y.;Chen Y.-C.;Wen L.-L.;Chien K.-L.;Sung F.-C.;Chen P.-C.;Ta-Chen Su | - |
dc.date.accessioned | 2020-09-28T02:47:36Z | - |
dc.date.available | 2020-09-28T02:47:36Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0013-9351 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84911389062&doi=10.1016%2fj.envres.2014.08.043&partnerID=40&md5=22b1b71eec7041d288cd8dd64565cc3a | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/514781 | - |
dc.description.abstract | Acrylamide is present in mainstream cigarette smoke and in some foods prepared at high temperatures. Animal studies have shown that acrylamide exposure alters thyroid function; however, it is not known if this also occurs in humans. The study examined the association between the urinary levels of the acrylamide metabolite and serum thyroid measures in adolescents and young adults. We recruited 793 subjects (mean age, 21.3 years; range, 12-30 years) from a population-based sample of Taiwanese adolescents and young adults to determine if the urinary levels of the acrylamide metabolite N-acetyl-. S-(propionamide)-cysteine (AAMA) and the 6 serum thyroid measures are associated. The mean (SD) AAMA were 76.54 (76.42) μg/L. Linear regression analyzes showed a 1-unit increase in natural log AAMA was significantly associated with a decrease in serum free thyroxine (T4) (ng/dL) (. β=-0.041, SE=0.013, p=0.001) after controlling for covariates. Subpopulation analyzes showed AAMA and free T4 were significantly associated with females, age 20-30 years, non-current smokers, and non-alcohol consumers. In conclusion, higher urinary AAMA concentrations were associated with decreased levels of free T4 in this cohort. Further studies are warranted to determine if there is a causal relationship between acrylamide exposure and thyroid function. ? 2014 Elsevier Inc. | - |
dc.publisher | Academic Press Inc. | - |
dc.relation.ispartof | Environmental Research | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | acrylamide; creatinine; cysteine derivative; liothyronine; n acetyl s (propionamide) cysteine; thyrotropin; thyroxine; thyroxine binding globulin; unclassified drug; acetylcysteine; N-acetyl-S-(propionamide)cysteine; adolescence; adult; age; amino acid; high temperature; hormone; measurement method; metabolite; subpopulation; adolescent; adult; Article; child; creatinine urine level; female; food processing; free thyroxine index; health program; human; kidney concentrating capacity; male; mass screening; smoking; Taiwanese; thyroid function; thyroxine blood level; urinalysis; urine level; analogs and derivatives; metabolism; physiology; thyroid gland; young adult; Acetylcysteine; Adolescent; Adult; Child; Female; Humans; Male; Thyroid Gland; Young Adult | - |
dc.title | Association between measurements of thyroid function and the acrylamide metabolite N-Acetyl-S-(propionamide)-cysteine in adolescents and young adults | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.envres.2014.08.043 | - |
dc.identifier.pmid | 25460643 | - |
dc.identifier.scopus | 2-s2.0-84911389062 | - |
dc.relation.pages | 246-252 | - |
dc.relation.journalvolume | 136 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Master's Program in Smart Medicine and Health Informatics (SMARTMHI) | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Institute of Environmental and Occupational Health Sciences | - |
crisitem.author.dept | Environmental and Occupational Medicine-NTUH | - |
crisitem.author.dept | Environmental and Occupational Medicine | - |
crisitem.author.dept | Environmental and Occupational Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-7505-6429 | - |
crisitem.author.orcid | 0000-0003-4979-8351 | - |
crisitem.author.orcid | 0000-0002-6242-5974 | - |
crisitem.author.orcid | 0000-0001-7523-7166 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | International College | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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