https://scholars.lib.ntu.edu.tw/handle/123456789/514786
標題: | Fine particulate matter results in hemodynamic changes in subjects with blunted nocturnal blood pressure dipping | 作者: | Chen S.-Y. CHANG-CHUAN CHAN Lin Y.-L. Hwang J.-S. TA-CHEN SU |
公開日期: | 2014 | 卷: | 131 | 起(迄)頁: | 1-5 | 來源出版物: | Environmental Research | 摘要: | Particulate matter with aerodynamic diameter of <2.5μm (PM2.5) is associated with blood pressure and hemodynamic changes. Blunted nocturnal blood pressure dipping is a major risk factor for cardiovascular events; limited information is available on whether PM2.5 exposure-related hemodynamic changes vary with day-night blood pressure circadian rhythms. In this study, we enrolled 161 subjects and monitored the changes in ambulatory blood pressure and hemodynamics for 24h. The day-night blood pressure and cardiovascular metrics were calculated according to the sleep-wake cycles logged in the subject[U+05F3]s diary. The effects of PM2.5 exposure on blood pressure and hemodynamic changes were analyzed using generalized linear mixed-effect model. After adjusting for potential confounders, a 10-μg/m3 increase in PM2.5 was associated with 1.0mmHg [95% confidence interval (CI): 0.2-1.8mmHg] narrowing in the pulse pressure, 3.1% (95% CI: 1.4-4.8%) decrease in the maximum rate of left ventricular pressure rise, and 3.6% (95% CI: 1.6-5.7%) increase in systemic vascular resistance among 79 subjects with nocturnal blood pressure dip of <10%. In contrast, PM2.5 was not associated with any changes in cardiovascular metrics among 82 subjects with nocturnal blood pressure dip of ?10%. Our findings demonstrate that short-term exposure to PM2.5 contributes to pulse pressure narrowing along with cardiac and vasomotor dysfunctions in subjects with nocturnal blood pressure dip of <10%. ? 2014 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896800318&doi=10.1016%2fj.envres.2014.01.009&partnerID=40&md5=f3747945d230b1306f2363c7f3762237 https://scholars.lib.ntu.edu.tw/handle/123456789/514786 |
ISSN: | 0013-9351 | DOI: | 10.1016/j.envres.2014.01.009 | SDG/關鍵字: | blood; cardiovascular system; circadian rhythm; health impact; health risk; particulate matter; adult; article; blood pressure monitoring; circadian rhythm; female; heart left ventricle pressure; hemodynamic monitoring; hemodynamic parameters; human; major clinical study; male; middle aged; particulate matter; priority journal; pulse pressure; sleep waking cycle; systemic vascular resistance; Blood pressure; Cardiac contractility; Circadian rhythm; Particulate matter; Vascular resistance; Adult; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiovascular Diseases; Circadian Rhythm; Female; Humans; Male; Middle Aged; Particulate Matter |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。