https://scholars.lib.ntu.edu.tw/handle/123456789/514870
Title: | The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults | Authors: | Chuang K.-J. CHANG-CHUAN CHAN TA-CHEN SU Lee C.-T. Tang C.-S. |
Issue Date: | 2007 | Journal Volume: | 176 | Journal Issue: | 4 | Start page/Pages: | 370-376 | Source: | American Journal of Respiratory and Critical Care Medicine | Abstract: | Rationale: The biological mechanisms linking air pollution to cardiovascular events still remain largerly unclear. Objectives: To investigate whether biological mechanisms linking air pollution to cardiovascular events occurred concurrently in human subjects exposed to urban air pollutants. Methods: We recruited a panel of 76 young, healthy students from a university in Taipei. Between April and June of 2004 or 2005, three measurements were made in each participant of high-sensitivity Creactive protein (hs-CRP), 8-hydroxy-2′-deoxyguanosine (8-OHdG), plasminogen activator fibrinogen inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA) in plasma, and heart rate variability (HRV). Gaseous air pollutants were measured at one air-monitoring station inside their campus, and particulate air pollutants were measured at one particulate matter supersite monitoring station 1 km from their campus.Weused linear mixed-effects models to associate biological endpoints with individual air pollutants averaged over 1- to 3-day periods before measurements were performed. Measurements and Main Results: We found that increases in hs-CRP, 8-OHdG, fibrinogen, and PAI-1, and decreases in HRV indices were associated with increases in levels of particles with aerodynamic diameters less than 10 μm and 2.5 μm, sulfate, nitrate, and ozone (O3) in single-pollutant models. The increase in 8-OHdG, fibrinogen, and PAI-1, and the reduction in HRV remained significantly associated with 3-day averaged sulfate and O3 levels in two-pollutant models. There were moderate correlations (r = -0.3) between blood markers of hs-CRP, fibrinogen, PAI-1, and HRV indices. Conclusions: Urban air pollution is associated with inflammation, oxidative stress, blood coagulation and autonomic dysfunction simultaneously in healthy young humans, with sulfate and O3 as two major traffic-related pollutants contributing to such effects. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34547941468&doi=10.1164%2frccm.200611-1627OC&partnerID=40&md5=9a888453f14f507a945072ccf173f91c https://scholars.lib.ntu.edu.tw/handle/123456789/514870 |
ISSN: | 1073-449X | DOI: | 10.1164/rccm.200611-1627OC | SDG/Keyword: | 8 hydroxydeoxyguanosine; C reactive protein; carbon monoxide; fibrinogen; nitrate; nitrogen dioxide; plasminogen activator inhibitor 1; sulfate; sulfur dioxide; tissue plasminogen activator; adult; air monitoring; air pollution; article; autonomic dysfunction; blood clotting; cardiovascular disease; enzyme linked immunosorbent assay; fibrinolysis; heart rate variability; human; human experiment; humidity; inflammation; normal human; oxidative stress; particulate matter; pneumonia; priority journal; statistical analysis; student; Taiwan; traffic; university student; Adolescent; Adult; Air Pollutants; Air Pollution; Biological Markers; Blood Coagulation; C-Reactive Protein; Deoxyguanosine; Environmental Monitoring; Female; Fibrinogen; Heart Rate; Humans; Inflammation; Male; Oxidative Stress; Particle Size; Plasminogen Activator Inhibitor 1; Taiwan; Tissue Plasminogen Activator; Urban Health; Urban Population |
Appears in Collections: | 醫學系 |
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