https://scholars.lib.ntu.edu.tw/handle/123456789/514870
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chuang K.-J. | en_US |
dc.contributor.author | CHANG-CHUAN CHAN | en_US |
dc.contributor.author | TA-CHEN SU | en_US |
dc.contributor.author | Lee C.-T. | en_US |
dc.contributor.author | Tang C.-S. | en_US |
dc.creator | Chuang K.-J.;Chan C.-C.;Ta-Chen Su;Lee C.-T.;Tang C.-S. | - |
dc.date.accessioned | 2020-09-28T02:47:57Z | - |
dc.date.available | 2020-09-28T02:47:57Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1073-449X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34547941468&doi=10.1164%2frccm.200611-1627OC&partnerID=40&md5=9a888453f14f507a945072ccf173f91c | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/514870 | - |
dc.description.abstract | Rationale: The biological mechanisms linking air pollution to cardiovascular events still remain largerly unclear. Objectives: To investigate whether biological mechanisms linking air pollution to cardiovascular events occurred concurrently in human subjects exposed to urban air pollutants. Methods: We recruited a panel of 76 young, healthy students from a university in Taipei. Between April and June of 2004 or 2005, three measurements were made in each participant of high-sensitivity Creactive protein (hs-CRP), 8-hydroxy-2′-deoxyguanosine (8-OHdG), plasminogen activator fibrinogen inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA) in plasma, and heart rate variability (HRV). Gaseous air pollutants were measured at one air-monitoring station inside their campus, and particulate air pollutants were measured at one particulate matter supersite monitoring station 1 km from their campus.Weused linear mixed-effects models to associate biological endpoints with individual air pollutants averaged over 1- to 3-day periods before measurements were performed. Measurements and Main Results: We found that increases in hs-CRP, 8-OHdG, fibrinogen, and PAI-1, and decreases in HRV indices were associated with increases in levels of particles with aerodynamic diameters less than 10 μm and 2.5 μm, sulfate, nitrate, and ozone (O3) in single-pollutant models. The increase in 8-OHdG, fibrinogen, and PAI-1, and the reduction in HRV remained significantly associated with 3-day averaged sulfate and O3 levels in two-pollutant models. There were moderate correlations (r = -0.3) between blood markers of hs-CRP, fibrinogen, PAI-1, and HRV indices. Conclusions: Urban air pollution is associated with inflammation, oxidative stress, blood coagulation and autonomic dysfunction simultaneously in healthy young humans, with sulfate and O3 as two major traffic-related pollutants contributing to such effects. | - |
dc.relation.ispartof | American Journal of Respiratory and Critical Care Medicine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.classification | [SDGs]SDG11 | - |
dc.subject.other | 8 hydroxydeoxyguanosine; C reactive protein; carbon monoxide; fibrinogen; nitrate; nitrogen dioxide; plasminogen activator inhibitor 1; sulfate; sulfur dioxide; tissue plasminogen activator; adult; air monitoring; air pollution; article; autonomic dysfunction; blood clotting; cardiovascular disease; enzyme linked immunosorbent assay; fibrinolysis; heart rate variability; human; human experiment; humidity; inflammation; normal human; oxidative stress; particulate matter; pneumonia; priority journal; statistical analysis; student; Taiwan; traffic; university student; Adolescent; Adult; Air Pollutants; Air Pollution; Biological Markers; Blood Coagulation; C-Reactive Protein; Deoxyguanosine; Environmental Monitoring; Female; Fibrinogen; Heart Rate; Humans; Inflammation; Male; Oxidative Stress; Particle Size; Plasminogen Activator Inhibitor 1; Taiwan; Tissue Plasminogen Activator; Urban Health; Urban Population | - |
dc.title | The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1164/rccm.200611-1627OC | - |
dc.identifier.pmid | 17463411 | - |
dc.identifier.scopus | 2-s2.0-34547941468 | - |
dc.relation.pages | 370-376 | - |
dc.relation.journalvolume | 176 | - |
dc.relation.journalissue | 4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Institute of Environmental and Occupational Health Sciences | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Environmental and Occupational Medicine | - |
crisitem.author.dept | Environmental and Occupational Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-7518-5236 | - |
crisitem.author.orcid | 0000-0001-7523-7166 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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