https://scholars.lib.ntu.edu.tw/handle/123456789/514974
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHE-WEI LIAO | en_US |
dc.contributor.author | Chia-Hung Chou | en_US |
dc.contributor.author | Xue-Ming Wu | en_US |
dc.contributor.author | ZHENG-WEI CHEN | en_US |
dc.contributor.author | YING-HSIEN CHEN | en_US |
dc.contributor.author | Yi-Yao Chang | en_US |
dc.contributor.author | VIN-CENT WU | en_US |
dc.contributor.author | Stefan Rose-John | en_US |
dc.contributor.author | CHI-SHENG HUNG | en_US |
dc.contributor.author | YEN-HUNG LIN | en_US |
dc.contributor.author | TAIPAI Study Group | en_US |
dc.date.accessioned | 2020-09-28T07:04:19Z | - |
dc.date.available | 2020-09-28T07:04:19Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0925-4439 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076533188&doi=10.1016%2fj.bbadis.2019.165627&partnerID=40&md5=fc37675a56525432a4f591d792979650 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/514974 | - |
dc.description.abstract | Macrophages play an important role in aldosterone-induced myocardial fibrosis, in which the first key steps are macrophage recruitment and infiltration. We hypothesized that IL-6 may be a key mediator of aldosterone-induced macrophage recruitment and infiltration. To test this hypothesis, we designed cell studies with a human monocytic cell line THP-1 that with monocyte/macrophage functions to explore the signaling pathway of aldosterone-induced macrophage infiltration, and further investigated the phenomenon and consequent pathway in aldosterone-infused mice studies. The results showed that aldosterone induced the expression of IL-6 via mineralocorticoid receptors, and enhanced THP-1 cell migration and infiltration. Further experiments using a protease array and siRNA revealed that expressions of MMP-1 and MMP-9 were associated with aldosterone-induced macrophage infiltration. In addition, aldosterone-induced MMP-1 and MMP-9 expressions were mediated via cyclooxygenase-II and prostaglandin E2/EP-2 and EP-4 receptors. In aldosterone-infused mice, mRNA expressions of MMP-1, MMP-9 and COX-2 in peripheral blood monocytic cells were significantly increased. Moreover, the number of mouse macrophage-restricted F4/80 protein-positive cells in the myocardium was significantly higher in the aldosterone-infused mice compared with control mice. The increase in F4/80-positive cells in the myocardium was suppressed in the aldosterone-infused mice with the aldosterone antagonist eplerenone or anti-IL-6 antibody treatment. In conclusion, interleukin-6 played an important role in aldosterone-induced macrophage recruitment and infiltration in the myocardium. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.ispartof | Biochimica et Biophysica Acta - Molecular Basis of Disease | en_US |
dc.subject | aldosterone | en_US |
dc.subject | interleukin 6 | en_US |
dc.subject | macrophage | en_US |
dc.subject | matrix metalloproteinase | en_US |
dc.title | Interleukin-6 plays a critical role in aldosterone-induced macrophage recruitment and infiltration in the myocardium | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.bbadis.2019.165627 | - |
dc.identifier.pmid | 31785407 | - |
dc.identifier.scopus | 2-s2.0-85076533188 | - |
dc.relation.pages | 165627 | en_US |
dc.relation.journalvolume | 1866 | en_US |
dc.relation.journalissue | 3 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUHYL | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-7156-5381 | - |
crisitem.author.orcid | 0000-0001-7728-6674 | - |
crisitem.author.orcid | 0000-0002-0585-5847 | - |
crisitem.author.orcid | 0000-0001-7935-0991 | - |
crisitem.author.orcid | 0000-0001-8153-1441 | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。