https://scholars.lib.ntu.edu.tw/handle/123456789/514982
標題: | Incidental Congestive Heart Failure in Patients With Aldosterone-Producing Adenomas | 作者: | Huang, Wei-Chieh Chen, Ying-Ying YEN-HUNG LIN Chen, Likwang Lin, Po-Chih YU-FENG LIN Liu, Yu-Chun Wu, Che-Hsiung SHIH-CHIEH CHUEH TZONG-SHINN CHU KWAN-DUN WU CHUN-YAO HUANG VIN-CENT WU |
公開日期: | 2019 | 出版社: | NLM (Medline) | 卷: | 8 | 期: | 24 | 起(迄)頁: | e012410 | 來源出版物: | Journal of the American Heart Association | 摘要: | Background-—Previous studies show that patients with primary aldosteronism are associated with higher risk of congestive heart failure (CHF). However, the effect of target treatment to the incidental CHF has not been elucidated. We aimed to investigate the risk of new-onset CHF in patients with aldosterone-producing adenomas (APAs) and explore the effect of adrenalectomy on new onset of CHF. Methods and Results-—From 1997 to 2009, 688 APA were identified and matched with essential hypertension controls. The risks of developing incidental CHF (hazard ratio, 0.49; 95% CI, 0.31–0.75; P=0.001) and mortality (hazard ratio, 0.29; 95% CI, 0.20–0.44; P<0.001) were significantly lower in the APA group after targeted treatment. A total of 605 patients with APAs who underwent adrenalectomy lowered the risks of CHF (subdistribution hazard ratio, 0.55; 95% CI, 0.34–0.90; P=0.017) and mortality (adjusted hazard ratio, 0.27; 95% CI, 0.16–0.44; P<0.001) compared with essential hypertension controls. Conclusions-—In conclusion, for patients with APAs, adrenalectomy can be associated with lower risk of incidental CHF and allcause mortality in a long-term follow-up. ? 2019 The Authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077843306&doi=10.1161%2fJAHA.119.012410&partnerID=40&md5=69bb861ac660090f245e1397c6335a2b https://scholars.lib.ntu.edu.tw/handle/123456789/514982 |
ISSN: | 2047-9980 | DOI: | 10.1161/JAHA.119.012410 | SDG/關鍵字: | aldosterone; adenoma; adrenal tumor; adrenalectomy; adult; aged; biosynthesis; cohort analysis; complication; female; heart failure; human; male; metabolism; middle aged; retrospective study; risk assessment; Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Aldosterone; Cohort Studies; Female; Heart Failure; Humans; Male; Middle Aged; Retrospective Studies; Risk Assessment |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。