https://scholars.lib.ntu.edu.tw/handle/123456789/514998
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chang C.-H. | en_US |
dc.contributor.author | SHIH-CHIEH CHUEH | en_US |
dc.contributor.author | VIN-CENT WU | en_US |
dc.contributor.author | Lin Y.-H. | en_US |
dc.contributor.author | YEN-HUNG LIN | en_US |
dc.contributor.author | KWAN-DUN WU | en_US |
dc.contributor.author | Tsai Y.-C. | en_US |
dc.contributor.author | Tsai Y.-C. | en_US |
dc.date.accessioned | 2020-09-28T07:04:25Z | - |
dc.date.available | 2020-09-28T07:04:25Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0039-6060 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056998162&doi=10.1016%2fj.surg.2018.08.020&partnerID=40&md5=4941d71848f7919502a731ac557858c4 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/514998 | - |
dc.description.abstract | Background: An elevated plasma aldosterone level has been reported as an independent risk factor for severe erectile dysfunction in men. The aim of this study was to explore whether primary hyperaldosteronism patients experience erectile dysfunction after targeted treatment. Methods: We conducted a population-based cohort study of men with newly identified primary hyperaldosteronism/aldosterone-producing adenoma from January 1, 1997, to December 31, 2009. Men with essential hypertension and normotension were matched to the primary hyperaldosteronism group according to propensity score matching. Results: We identified 1,067 men with primary hyperaldosteronism (mean age, 46.7 ± 12.8 years) and matched them with the same number of men with essential hypertension or normotension. During the mean follow-up interval of 5.4 years, the incident rates of total erectile dysfunction were 5.7, 3.9, and 3.1 per 1,000 person-years for the primary hyperaldosteronism, essential hypertension, and normotension groups, respectively. Men with primary hyperaldosteronism exhibited a higher risk of erectile dysfunction compared with men with normotension (competing risks hazard ratio, 1.83), and no difference was seen in comparison with men who have essential hypertension. After adrenalectomy, men who have primary hyperaldosteronism had a higher risk of exhibiting severe erectile dysfunction compared with men who have essential hypertension (competing risks hazard ratio, 2.44) or normotension (competing risks hazard ratio, 2.90). Conclusion: Men with primary hyperaldosteronism reported a higher incidence of severe erectile dysfunction than normotension controls despite targeted treatment. The risk of severe erectile dysfunction increased after men who have primary hyperaldosteronism underwent adrenalectomy. This result raises the possibility of severe erectile dysfunction after adrenalectomy and calls for a prospective large-scale study of men who have aldosterone-producing adenoma regarding their erectile function both before and after adrenalectomy. ? 2018 | en_US |
dc.publisher | Mosby Inc. | en_US |
dc.relation.ispartof | Surgery (United States) | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | mineralocorticoid antagonist; adrenalectomy; adult; aldosterone blood level; Article; cohort analysis; controlled study; disease severity; erectile dysfunction; essential hypertension; follow up; human; incidence; major clinical study; male; middle aged; population research; primary hyperaldosteronism; priority journal; propensity score; risk assessment; risk factor; blood; clinical trial; complication; erectile dysfunction; health survey; hyperaldosteronism; multicenter study; propensity score; retrospective study; Taiwan; Erectile Dysfunction; Follow-Up Studies; Humans; Hyperaldosteronism; Incidence; Male; Middle Aged; Population Surveillance; Propensity Score; Retrospective Studies; Taiwan | - |
dc.title | Risk of severe erectile dysfunction in primary hyperaldosteronism: A population-based propensity score matching cohort study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.surg.2018.08.020 | - |
dc.identifier.pmid | 30473204 | - |
dc.identifier.scopus | 2-s2.0-85056998162 | - |
dc.relation.pages | 622-628 | en_US |
dc.relation.journalvolume | 165 | en_US |
dc.relation.journalissue | 3 | en_US |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-0713-4904 | - |
crisitem.author.orcid | 0000-0001-7935-0991 | - |
crisitem.author.orcid | 0000-0001-8153-1441 | - |
crisitem.author.orcid | 0000-0002-3339-1509 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。